908600-73-7 Usage
Molecular Structure
1H-Indole-5-carboxylic acid, 6-fluoro, is a chemical compound with a core structure of indole, which is a bicyclic aromatic system consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. The carboxyl group (-COOH) is attached to the five-membered ring, and a fluorine atom is present at the 6-position of the indole ring.
Substitution
1H-INDOLE-5-CARBOXYLIC ACID,6-FLUORO is a substituted indolecarboxylic acid, with the fluorine atom being the substituent. The presence of the fluorine atom makes it a fluorinated derivative of indole.
Biological Activity
1H-Indole-5-carboxylic acid, 6-fluoro, has been studied for its potential biological activities, including anti-inflammatory, anticancer, and antiviral properties.
Synthesis Building Block
1H-INDOLE-5-CARBOXYLIC ACID,6-FLUORO is commonly used as a building block in the synthesis of various pharmaceutical and agrochemical compounds, making it a versatile chemical intermediate.
Drug Development
1H-Indole-5-carboxylic acid, 6-fluoro, is utilized in the development of new drug candidates, as well as a precursor for the preparation of diverse chemical entities.
Medicinal Chemistry and Drug Discovery
Due to its potential applications and biological activities, 1H-INDOLE-5-CARBOXYLIC ACID,6-FLUORO plays an important role in the field of medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 908600-73-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,8,6,0 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 908600-73:
(8*9)+(7*0)+(6*8)+(5*6)+(4*0)+(3*0)+(2*7)+(1*3)=167
167 % 10 = 7
So 908600-73-7 is a valid CAS Registry Number.
908600-73-7Relevant academic research and scientific papers
In search of simplicity and flexibility: A rational access to twelve fluoroindolecarboxylic acids
Schlosser, Manfred,Ginanneschi, Assunta,Leroux, Frederic
, p. 2956 - 2969 (2007/10/03)
All twelve indolecarboxylic acids 1-12 carrying both a fluorine substituent and a carboxy group at the benzo ring have been prepared either directly from the corresponding fluoroindoles 13-16 or from the chlorinated derivatives 22, 23 and 25 by hydrogen/metal permutation ("metalation"), or from the bromo- or iodofluoroindoles 17-20 and 26, 27, 29 and 30 by halogen/metal permutation, the organometallic intermediate being each time trapped with carbon dioxide. In most, though not all cases, the nitrogen atom in the five-membered ring had to be protected by a trialkylsilyl group. Some of the bromo- or iodofluoroindoles (26 and 27) were successfully subjected to a basicity gradient-driven selective migration of the heavy halogen. An unexpected finding on the way to the target compounds were the rigorously site-selective metalation of the 5-fluoro-N-(trialkylsilyl)indole (14b; exclusive deprotonation of the 4-position). The fluoroindoles 13-16, although previously known, were accessed more conveniently from suitably substituted nitrobenzenes using the Bartoli or the Leimgruber-Batcho method. A new and very attractive indole synthesis was elaborated consisting of the ortho-lithiation of an N-acyl-protected aniline followed by ortho-formylation, Wittig chloromethylenation and base-catalyzed cyclization accompanied by dehydrochlorination. These five consecutive steps can be contracted to a convenient one-pot protocol. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
