90870-33-0Relevant academic research and scientific papers
Two-step activity-based protein profiling of diacylglycerol lipase
Van Rooden, Eva J.,Kreekel, Roy,Hansen, Thomas,Janssen, Antonius P. A.,Van Esbroeck, Annelot C. M.,Den Dulk, Hans,Van Den Berg, Richard J. B. H. N.,Codée, Jeroen D. C.,Van Der Stelt, Mario
supporting information, p. 5250 - 5253 (2018/08/03)
Diacylglycerol lipases (DAGL) produce the endocannabinoid 2-arachidonoylglycerol, a key modulator of neurotransmitter release. Chemical tools that visualize endogenous DAGL activity are desired. Here, we report the design, synthesis and application of a triazole urea probe for DAGL equipped with a norbornene as a biorthogonal handle. The activity and selectivity of the probe was assessed with activity-based protein profiling. This probe was potent against endogenous DAGLα (IC50 = 5 nM) and it was successfully applied as a two-step activity-based probe for labeling of DAGLα using an inverse electron-demand Diels-Alder ligation in living cells.
SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS
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Paragraph 0180; 0702, (2015/04/21)
Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
Morton, Daniel,Leach, Stuart,Cordier, Christopher,Warriner, Stuart,Nelson, Adam
supporting information; experimental part, p. 104 - 109 (2009/04/12)
(Chemical Equation Presented) Seeking scaffold diversity: A synthetic approach for the combinatorial variation of the scaffolds of small molecules is described. Using just six basic reaction types, compounds with 84 distinct scaffolds were prepared. The c
