90871-39-9Relevant academic research and scientific papers
Co-Catalyzed Intramolecular S-N Bond Formation in Water for 1,2-Benzisothiazol-3(2H)-ones and 1,2,4-Thiadiazoles Synthesis
Yang, Liting,Song, Lijuan,Tang, Shanyu,Li, Longjia,Li, Heng,Yuan, Bingxin,Yang, Guanyu
, p. 1281 - 1285 (2019/01/14)
An efficient and versatile Co-catalyzed intramolecular S-N bond formation in water to synthesize 1,2-benzisothiazol-3(2H)-one and 1,2,4-thiadiazoles derivatives in good to excellent yields was developed. The transformation showed great tolerance with a broad range of substituents. The mother liquor was able to be recycled 6 times with minor loss in product yield.
Synthesis of 5-Amino and 3,5-Diamino Substituted 1,2,4-Thiadiazoles by I2-Mediated Oxidative N-S Bond Formation
Wang, Bingnan,Meng, Yinggao,Zhou, Yiming,Ren, Linning,Wu, Jie,Yu, Wenquan,Chang, Junbiao
, p. 5898 - 5903 (2017/06/07)
An oxidative N-S bond formation reaction has been established for 1,2,4-thiadiazole synthesis employing molecular iodine as the sole oxidant. The features of the present reaction include no use of transition metals, mild reaction conditions, simple operat
Boulton-Katritzky Rearrangement of 5-(Cyanoimino)-1,2,4-thiadiazolines
Sonnenschein, Helmut,Schmitz, Ernst,Gruendemann, Egon,Schroeder, Edith
, p. 1177 - 1180 (2007/10/02)
The products of the addition of nucleophiles (alcohols, amines) to the cyano group of 5-(cyanoimino)thiadiazolines 1 undergo a Boulton-Katritzky rearrangement.The thiadiazoles 4 are formed by subsequent nitrile elimination.In the case of bicyclic thiadiazoloazepine 5 an equilibrium mixture of unrearranged iminothiadiazoline 6 and rearranged thiadiazole 7 is obtained as an intermediate. - Key Words: 1,2,4-Thiadiazoles / Bond switch / Nucleophiles, selective reaction
