90875-84-6Relevant academic research and scientific papers
The Catalyst-Controlled Regiodivergent Chlorination of Phenols
Maddox, Sean M.,Dinh, Andrew N.,Armenta, Felipe,Um, Joann,Gustafson, Jeffrey L.
supporting information, p. 5476 - 5479 (2016/11/17)
Different catalysts are demonstrated to overcome or augment a substrate's innate regioselectivity. Nagasawa's bis-thiourea catalyst was found to overcome the innate para-selectivity of electrophilic phenol chlorination, yielding ortho-chlorinated phenols that are not readily obtainable via canonical electrophilic chlorinations. Conversely, a phosphine sulfide derived from 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) was found to enhance the innate para-preference of phenol chlorination.
NO-RELEASING NITROOXY-CHROMENE CONJUGATES
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Paragraph 0302; 0303, (2016/12/16)
The present invention provides NO-releasing nitrooxy-alkylenyl-linked-chromene conjugates, having the structure of Formula (1) wherein R1, R2, R3, R4, X, and L are as defined in the detailed description; pharmaceutical compositions comprising at least one compound o Formula (I); and methods useful for healing wounds, preventing and treating cancer and treating actinic keratosis, cystic fibrosis, and acne, using a compound of Formula (1).
NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES
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Paragraph 0211; 0212, (2015/08/03)
The present invention provides NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, or acne, using a compound of Formula (I).
NO-RELEASING NITROOXY-CHROMENE CONJUGATES
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Paragraph 0212; 0213, (2015/08/03)
The present invention provides NO-releasing nitrooxy-alkylenyl-linked-chromene conjugates, having the structure of Formula (1 ) wherein R1, R2, R3, R4, X, and L are as defined in the detailed description; pharmaceutical compositions comprising at least one compound o Formula (I); and methods useful for healing wounds, preventing and treating cancer and treating actinic keratosis, cystic fibrosis, and acne, using a compound of Formula (1).
NO-RELEASING GUANIDINE-CHROMENE CONJUGATES
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Paragraph 0270; 0271, (2015/07/22)
The present disclosure provides NO-releasing guanidine-chromene conjugates, having the structure of Formula (I): wherein R1, R2, R3, R4, R10, and L are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, acne, or a disease mediated by arginine deficiency using a compound of Formula (I).
Preparation of 4-Bromo- and 4-Chloro-3-t-butylphenol
Fukata, Gouki,Kubota, Yukihiro,Mataka, Shuntaro,Thiemann, Thies,Tashiro, Masashi
, p. 592 - 594 (2007/10/02)
4-Bromo- and 4-Chloro-3-butylphenol, two potent fungistatics, were prepared in an efficient 3-step synthesis from commercially available materials.Crucial to the synthesis is the use of halo-substituents as positional protective groups.
Tert-Butyl-halophenols
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, (2008/06/13)
3-tert-Butyl-4-halophenols which are useful as intermediates for preparing compounds having medical or agricultural activities.
