908831-83-4

Basic information

• Product Name: N-(6-methyl-2-pyridinecarbonyl)-3-chloroaminobenzene
• Synonyms: N-(6-methyl-2-pyridinecarbonyl)-3-chloroaminobenzene
• CAS NO: 908831-83-4
• Molecular Weight: 246.696
• Mol File: 908831-83-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(6-methyl-2-pyridinecarbonyl)-3-chloroaminobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-methyl-2-pyridinecarbonyl)-3-chloroaminobenzene(908831-83-4)
• EPA Substance Registry System: N-(6-methyl-2-pyridinecarbonyl)-3-chloroaminobenzene(908831-83-4)

Safety Data

• Hazardous Substances Data: 908831-83-4(Hazardous Substances Data)

Upstream product

• 126125-54-0 6-methyl-pyridine-2-carbonyl chloride 
• 108-42-9 3-chloro-aniline 
• 934-60-1 6-methyl-2-pyridinecarboxylic acid 
• 1344728-77-3 N-(6-methyl-2-pyridinecarbothionyl)-3-ethoxyaminobenzene 

Relevant articles and documents

Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists

We described here the synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as potential mGluR5 antagonists. We found that a series of thiazole derivatives 6 showed better inhibitory activity against mGluR5. Compounds 6bc and 6bj have been identified as potent antagonists (IC50 = 274 and 159 nM) showing excellent in vitro stability profile. Molecular docking study using the crystal structure of mGluR5 revealed that our compounds 6bc and 6bj fit the allosteric binding site of mavoglurant well.

Pyridine-2-carboxyamide derivatives

The invention relates to compounds of formula I: wherein R1 to R3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for treating CNS disorders.