90888-04-3Relevant academic research and scientific papers
NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
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Page/Page column 27; 28, (2015/02/25)
Novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
Synthesis and properties of a novel type of acyclic nucleoside phosphonates: 2-(purin-9-yl)ethoxyphenylphosphonic acids
Hockova, Dana,Dracinsky, Martin,Holy, Antonin
scheme or table, p. 2885 - 2892 (2010/08/05)
A series of novel acyclic nucleoside phosphonates with a built-in arylphosphonate moiety has been prepared by a microwave-assisted cross-coupling reaction as the key step. Their cytostatic and antiviral activities were tested. The pKa values of the target ortho-, meta- and para-substituted arylphosphonates were determined by 31P NMR titration studies.
High-yielding cleavage of (aryloxy)acetates
Spurg, Anke,Waldvogel, Siegfried R.
, p. 337 - 342 (2008/09/18)
A reliable and high-yielding one-pot sequence for the removal of O-carboxymethyl moieties from phenols is presented. When diethylphosphoryl azide is employed as the azide transfer reagent in the Curtius rearrangement and glycerol in the subsequent hydrolytic workup, the protocol can be reliably applied to a very broad scope of substrates. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes
Christiansen, Elisabeth,Urban, Christian,Merten, Nicole,Liebscher, Kathrin,Karlsen, Kasper K.,Hamacher, Alexandra,Spinrath, Andreas,Bond, Andrew D.,Drewke, Christel,Ullrich, Susanne,Kassack, Matthias U.,Kostenis, Evi,Ulven, Trond
scheme or table, p. 7061 - 7064 (2009/11/30)
A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA1) has been discovered and explored. The preferred compound 20 (TUG-424, EC50 = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity.
