90891-07-9Relevant academic research and scientific papers
On the synthesis, characterization and reactivity of n-heteroaryl-boryl radicals, a new radical class based on five-membered ring ligands
Tehfe, Mohamad-Ali,Schweizer, Stephane,Chany, Anne-Caroline,Ysacco, Cedric,Clement, Jean-Louis,Gigmes, Didier,Morlet-Savary, Fabrice,Fouassier, Jean-Pierre,Neuburger, Markus,Tschamber, Theophile,Blanchard, Nicolas,Lalevee, Jacques
, p. 5054 - 5063 (2014/05/06)
The synthesis and physical characterization of a new class of N-heterocycle-boryl radicals is presented, based on five membered ring ligands with a N(sp2) complexation site. These pyrazole-boranes and pyrazaboles exhibit a low bond dissociation energy (BDE; B-H) and accordingly excellent hydrogen transfer properties. Most importantly, a high modulation of the BDE(B-H) by the fine tuning of the N-heterocyclic ligand was obtained in this series and could be correlated with the spin density on the boron atom of the corresponding radical. The reactivity of the latter for small molecule chemistry has been studied through the determination of several reaction rate constants corresponding to addition to alkenes and alkynes, addition to O 2, oxidation by iodonium salts and halogen abstraction from alkyl halides. Two selected applications of N-heterocycle-boryl radicals are also proposed herein, for radical polymerization and for radical dehalogenation reactions.
Preparation of organomanganese reagents from organic halides with activated manganese
Kakiya, Hirotada,Nishimae, Shinji,Shinokubo, Hiroshi,Oshima, Koichiro
, p. 8807 - 8815 (2007/10/03)
Reduction of Li2MnCl4 with magnesium metal provided activated manganese as a black suspension in THF. Treatment of organic halides such as allyl bromides, α-halo esters or aryl halides with activated manganese furnished various organomanganese reagents which reacted further with electrophiles to afford the corresponding adducts. The reaction of a ketone bearing an iodoaryl moiety with this active manganese induced cyclization to provide dihydroindene derivative.
Therapeutic dipeptides
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, (2008/06/13)
(3S)-2-N-[(1S)-1-Ethoxycarbonyl-1-(2,3-dihydro-1H-inden-2-yl)-methyl]-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a antihypertensive agent.
