81577-34-6

Upstream product

• 598-78-7 (R,S)-2-chloropropionic acid 
• 100-51-6 benzyl alcohol 
• 27816-36-0 2-Chloropropionamide 
• 140-11-4 Benzyl acetate 
• 17639-93-9 2-chloro-propionic acid methyl ester 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 
• 7623-09-8 2-chloropropionyl chloride 

Downstream Products

• 59011-59-5 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-propionic acid benzyl ester 
• 91497-67-5 2-Carboxymethylmercapto-propionsaeure-benzylester 
• 122-63-4 benzyl proprionate 
• 90891-07-9 benzyl 2-iodopropanoate 
• 147649-96-5 (+/-)-benzyl-2-methyl-4-pentenoate 

Relevant academic research and scientific papers

PYRIDINONE AND PYRIMIDINONE PHOSPHATES AND BORONATES USEFUL AS ANTIBACTERIAL AGENTS

The present invention is directed to new pyridinone or pyrimidinone hydroxamic acid phosphates of Formula (1 ) and boronates of Formula (2), stereoisomers thereof; wherein Q is selected from the group consisting of -P(0)(OH)2, -P(0)(OH)(0"M+), - P(0)(0"M+)2 and -P(0)(0")2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation; X is CH or N; and Z is as defined herein; and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

SUBSTITUTED 3-PHENYLQUINAZOLIN-4(3H)-ONES AND USES THEREOF

The present invention covers substituted 3-Phenylquinazolin-4(3H)-one compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of various inflammatory and fibrotic diseases of the respiratory tract and of the lungs as well as lung cancer, as a sole agent or in combination with other active ingredients.

Heteroleptic 1D coordination polymers: 5-Coordinated zinc(II) polymer as an efficient transesterification catalyst

The synthesis of three 1D coordination polymers (CPs), [Zn(TPPZ)(HCCB)]n·DMF·H2O (1) [Cd(TPPZ)(HCCB)]n(2) and [Co(TPPZ)(HCCB)]n(3), based on the N,N,N-chelating κ3-2,3,5,6-tetrakis(2-pyridyl)pyrazine (TPPZ) and polymerizing carboxylate (–COO?) 3-(carboxy-methylamino)-4-chlorobenzoic acid (H3CCB) ligands, using a solvothermal method, have been described. The CPs have been adequately characterized by satisfactory elemental analyses, FT-IR, UV–vis, emission, TGA and PXRD analysis. The structure of 1 has been verified by single crystal X-ray diffraction analysis. The structural data revealed the 5-coordinated heteroleptic polymeric framework is exclusively extended through the H3CCB carboxylate group and strong N,N,N-chelating TPPZ ligand acts as a branch terminating site. Notably, the structure of 1 is comprised of one unit of each H2O and DMF solvent in its crystal lattice. In contrast, 2 and 3 exclude lattice solvents, as suggested by PXRD studies, after thermal desolvation of 1. Furthermore, 1 with 5-coordinated Zn(II) centers exhibited an efficient catalytic performance for transesterification reactions, with remarkable stability and good reusability.

ZINC COMPLEX

A zinc complex characterized in exhibiting an octahedral structure and being configured from repeating units represented by general formula (I): wherein L represents a linker region, and R1 represents a C1-4 alkyl group, which can have a halogen atom.

Scandium triflate catalyzed ester synthesis using primary amides

A scandium triflate (ScOTf)3 catalyzed methodology has been developed to synthesize esters from primary amides. Various primary and secondary aliphatic alcohols have been shown to react in n-heptane with a range of primary amides for 24 h.

N-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. Formula (I).

Environmentally friendly transesterification and transacylation reactions under libr catalysis

A room-temperature, convenient transesterification of various esters, induced by catalytic amounts of lithium bromide and diethylamine in a solvent-free environment, is described. Products are obtained in good purity by simple filtration to remove the catalyst and evaporation of the volatile portion. The procedure has also been successfully applied to transacetylation and aminolysis of esters. Springer-Verlag 2010.

Preparation of organomanganese reagents from organic halides with activated manganese

Reduction of Li2MnCl4 with magnesium metal provided activated manganese as a black suspension in THF. Treatment of organic halides such as allyl bromides, α-halo esters or aryl halides with activated manganese furnished various organomanganese reagents which reacted further with electrophiles to afford the corresponding adducts. The reaction of a ketone bearing an iodoaryl moiety with this active manganese induced cyclization to provide dihydroindene derivative.