909002-34-2

Upstream product

• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 909002-32-0 (-)-3-[2-(S)-(1-nitro-3,3,3-trifluoropropyl)]-[4-(R)-phenyl]-oxazolidin-2-one 

Downstream Products

• 120-93-4 imidazolidone 
• 909002-37-5 2-(1-aminomethyl-2,2,2-trifluoroethylamino)-2-phenylethanol 
• 909002-35-3 (-)-1-[2-hydroxy-1-(R)-phenylethyl]-5-(S)-trifluoromethylimidazolidin-2-one 

Relevant academic research and scientific papers

Stereoselective synthesis of trifluoromethyl-substituted 1,2-diamines by aza-Michael reaction with trans-3,3,3-trifluoro-1-nitropropene

Aza-Michael addition of optically pure 4-phenyl-2-oxazolidinone to 3,3,3-trifluoro-1-nitropropene proceeds smoothly at low temperature with a high yield. Diastereoselectivity of the addition depends on the base used and lithiated species proved to be highly efficient affording 92% de. Optically pure 1,2-diamino-3,3,3-trifluoropropane is prepared in 58% yield from the aza-Michael addition product through a three-step procedure.

6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES

The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.