909002-37-5

Basic information

• Product Name: 2-(1-aminomethyl-2,2,2-trifluoroethylamino)-2-phenylethanol
• Synonyms: 2-(1-aminomethyl-2,2,2-trifluoroethylamino)-2-phenylethanol
• CAS NO: 909002-37-5
• Molecular Weight: 248.248
• Mol File: 909002-37-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-aminomethyl-2,2,2-trifluoroethylamino)-2-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-aminomethyl-2,2,2-trifluoroethylamino)-2-phenylethanol(909002-37-5)
• EPA Substance Registry System: 2-(1-aminomethyl-2,2,2-trifluoroethylamino)-2-phenylethanol(909002-37-5)

Safety Data

• Hazardous Substances Data: 909002-37-5(Hazardous Substances Data)

Upstream product

• 909002-34-2 (-)-3-[2-(S)-(1-amino-3,3,3-trifluoropropyl)]-[4-(R)-phenyl]-oxazolidin-2-one 
• 107-15-3 ethylenediamine 
• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 909002-32-0 (-)-3-[2-(S)-(1-nitro-3,3,3-trifluoropropyl)]-[4-(R)-phenyl]-oxazolidin-2-one 

Relevant articles and documents

Stereoselective synthesis of trifluoromethyl-substituted 1,2-diamines by aza-Michael reaction with trans-3,3,3-trifluoro-1-nitropropene

Aza-Michael addition of optically pure 4-phenyl-2-oxazolidinone to 3,3,3-trifluoro-1-nitropropene proceeds smoothly at low temperature with a high yield. Diastereoselectivity of the addition depends on the base used and lithiated species proved to be highly efficient affording 92% de. Optically pure 1,2-diamino-3,3,3-trifluoropropane is prepared in 58% yield from the aza-Michael addition product through a three-step procedure.