90909-57-2

Upstream product

• 16231-67-7 methyl 2'-formyl-[1,1'-biphenyl]-2-carboxylate 
• 73178-79-7 3'-chloro-[1,1'-biphenyl]-2-carboxylic acid 
• 63503-60-6 3-chlorophenylboronic acid 
• 773134-22-8 C₁₄H₁₁ClO₂ 
• 610-97-9 o-iodo-methyl-benzoic acid 

Relevant academic research and scientific papers

Scalable Electrochemical Dehydrogenative Lactonization of C(sp2/sp3)-H Bonds

A practical, electrochemical method is developed for the direct dehydrogenative lactonization of C(sp2/sp3)-H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature of this newly developed electrochemical process was demonstrated on a 40 g scale following an operationally simple protocol. The remote lactonization of C(sp3)-H bonds would constitute an important synthetic advance toward electrochemical C-O bond formation.

Photocatalytic Dehydrogenative Lactonization of 2-Arylbenzoic Acids

A metal-free dehydrogenative lactonization of 2-arylbenzoic acids at room temperature was developed. This work illustrates the first application of visible-light photoredox catalysis in the preparation of benzo-3,4-coumarins, an important structural motif in bioactive molecules. The combination of photocatalyst [Acr+-Mes] with (NH4)2S2O8 as a terminal oxidant provides an economical and environmentally benign entry to different substituted benzocoumarins. Preliminary mechanistic studies suggest that this reaction most likely occurs through a homolytic aromatic substitution pathway.

Abnormal Products from the Exhaustive Ozone Oxidation of Phenanthrene in HCl/Methanol

Exhaustive ozone treatment of phenanthrene (6) in HCl/methanol afforded unsubstituted (10a) and chloro-substituted 6H-dibenzopyran-6-ones (10b - d) in addition to the expected dimethyl 2,2'-biphenyldicarboxylate (9c).