90923-90-3

Upstream product

• 13735-81-4 1-styrenyloxytrimethylsilane 
• 50609-85-3 (E)-3-methylamino-3-methylthio-1-phenylprop-2-ene-1-thione 
• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 
• 186581-53-3 diazomethane 
• 2825-30-1 5-phenyl-isothiazol-3-one 

Downstream Products

• 90766-40-8 4-bromo-2-methyl-5-phenyl-isothiazol-3-one 
• 57027-49-3 3-bromo-5-phenyl-isothiazole 
• 19983-39-2 3-chloro-5-phenylisothiazole 

Relevant academic research and scientific papers

Novel synthesis of 3-alkyl-2,5-diaryl-1,4-oxathiepin-7-ones

N-Acetyl-N-methyl-3-aryl-3-[1-(aroyl)ethylthio]-2-propaneamides, prepared from thioaroylketene S,N-acetals, Hg(OAc)2 and silyl enol ethers of aryl-1-propanones in CH2Cl2 at rt, reacted with NaH in THF to give the title compounds in excellent yields.

Reactions of thiobenzoylketene S,N-acetals with silyl enol ethers of cyclic ketones in the presence of desilylating reagents: formation and desulfurization of thienolactams

Medium-sized thienolactams can be directly prepared from thiobenzoylketene S,N-acetals, Hg(OAc)2, and silyl enol ethers of cyclic ketones, and either TBAF or TASF. However, by adding either water or alcohol to the foregoing mixture, 3-methylamino-5-phenylthiophenes, in which the ω-position of long-chain alkanoic acids and alkanoic esters are bonded to C-2 of the thiophene ring, can be obtained albeit in low yields. Sequential treatment of the thienolactams with Raney nickel and Adam's catalyst result in completely reductive desulfurization of thienolactams molecules.