90924-46-2 Usage
General Description
Methyl 2-oxindole-4-carboxylate is an organic compound with the molecular formula C11H9NO3. It is a derivative of oxindole, a heterocyclic compound containing a five-membered ring with nitrogen and oxygen atoms. Methyl 2-oxindole-4-carboxylate is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It can also be utilized in the production of dyes and other organic compounds. Its properties and reactivity make it a valuable intermediate in organic synthesis and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 90924-46-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,9,2 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 90924-46:
(7*9)+(6*0)+(5*9)+(4*2)+(3*4)+(2*4)+(1*6)=142
142 % 10 = 2
So 90924-46-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO3/c1-14-10(13)6-3-2-4-8-7(6)5-9(12)11-8/h2-4H,5H2,1H3,(H,11,12)
90924-46-2Relevant articles and documents
Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation
Xie, Zhouling,Zhou, Youli,Zhao, Wei,Jiao, He,Chen, Yu,Yang, Yong,Li, Zhiyu
supporting information, p. 4557 - 4561 (2015/10/12)
A series of AG014699 derivatives containing a novel scaffold of 2,3-dihydro-1H-[1,2]diazepino[4,5,6-cd]indole-1,4(6H)-dione were synthesized and evaluated for their inhibitory activities toward PARP-1 enzyme and two cell lines, MCF-7 cells and the BRCA1-deficient MDA-MB-436 cells. Our results demonstrated that of all AG014699 derivatives synthesized in this work, compounds 6 and 7 showed strong PARP-1 inhibitory activity (IC50 = 3.5 nM and 2.4 nM, respectively), only four and three times less potent than AG014699. Compound 6 also had significantly cell inhibitory activity against both MCF-7 cells (CC50 = 25.8 μM) and the BRCA1-deficient MDA-MB-436 cells (CC50 = 5.4 μM), nearly as good as AG014699, indicating that it can be a promising compound for further evaluation.