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90924-46-2

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90924-46-2 Usage

General Description

Methyl 2-oxindole-4-carboxylate is an organic compound with the molecular formula C11H9NO3. It is a derivative of oxindole, a heterocyclic compound containing a five-membered ring with nitrogen and oxygen atoms. Methyl 2-oxindole-4-carboxylate is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It can also be utilized in the production of dyes and other organic compounds. Its properties and reactivity make it a valuable intermediate in organic synthesis and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 90924-46-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,9,2 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 90924-46:
(7*9)+(6*0)+(5*9)+(4*2)+(3*4)+(2*4)+(1*6)=142
142 % 10 = 2
So 90924-46-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO3/c1-14-10(13)6-3-2-4-8-7(6)5-9(12)11-8/h2-4H,5H2,1H3,(H,11,12)

90924-46-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-oxo-1,3-dihydroindole-4-carboxylate

1.2 Other means of identification

Product number -
Other names 2-oxo-2,3-dihydro-1H-indole-4-carboxylic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:90924-46-2 SDS

90924-46-2Relevant articles and documents

Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation

Xie, Zhouling,Zhou, Youli,Zhao, Wei,Jiao, He,Chen, Yu,Yang, Yong,Li, Zhiyu

supporting information, p. 4557 - 4561 (2015/10/12)

A series of AG014699 derivatives containing a novel scaffold of 2,3-dihydro-1H-[1,2]diazepino[4,5,6-cd]indole-1,4(6H)-dione were synthesized and evaluated for their inhibitory activities toward PARP-1 enzyme and two cell lines, MCF-7 cells and the BRCA1-deficient MDA-MB-436 cells. Our results demonstrated that of all AG014699 derivatives synthesized in this work, compounds 6 and 7 showed strong PARP-1 inhibitory activity (IC50 = 3.5 nM and 2.4 nM, respectively), only four and three times less potent than AG014699. Compound 6 also had significantly cell inhibitory activity against both MCF-7 cells (CC50 = 25.8 μM) and the BRCA1-deficient MDA-MB-436 cells (CC50 = 5.4 μM), nearly as good as AG014699, indicating that it can be a promising compound for further evaluation.

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