90933-75-8

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 98325-53-2 [1-(3-Methoxy-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine 

Downstream Products

• 90933-80-5 C₁₇H₂₀NO₂ 
• 1162673-62-2 (S)-1-(3-methoxyphenyl)-N-methyl-N-[(S)-1-phenylethyl]ethanamine 

Relevant academic research and scientific papers

B(C6F5)3-Catalyzed Asymmetric Reductive Amination of Ketones with Ammonia Borane

The first example of metal-free B(C6F5)3-catalyzed asymmetric reduction amination of ketones with chiral α-methylbenzylamine (α-MBA) using ammonia borane as the reductant is reported. This one-pot method has a broad substrate scope and provides various chiral amines in 81-95% yield with 80-99% de. This protocol was further applied in the total synthesis of cinacalcet.

Diastereoselective Synthesis of Chiral Secondary Amines with Two Chiral Centers Directly Attached to the Nitrogen Atom

The synthesis of the amines 1a-f by hydrogenation of the corresponding imines 4a-f occurs with a diastereoselectivity ranging from 33percent to higher than 90percent.The absolute configurations of 1b-f have been determined by either X-ray analysis (1b and