909406-74-2

Usage

Uses

Used in Organic Synthesis:
Ethyl 6-oxaspiro[2.5]octane-1-carboxylate is used as a building block in organic synthesis for its unique spiro ring structure and carboxylate functional group, which contribute to the formation of diverse chemical compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, Ethyl 6-oxaspiro[2.5]octane-1-carboxylate is employed as a key intermediate in the synthesis of pharmaceuticals. Its distinctive structural features make it a promising candidate for the development of new drugs and therapeutic agents.
Used in the Creation of Fine Chemicals:
Ethyl 6-oxaspiro[2.5]octane-1-carboxylate is also utilized in the production of fine chemicals due to its unique properties and the versatility it offers in chemical reactions. This makes it a valuable component in various specialized chemical applications.

Upstream product

• 130312-00-4 ethyl tetrahydro-4H-pyran-4-ylideneacetate 
• 1030268-24-6 trimethylsulphoxonium iodide 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 1774-47-6 trimethylsulfoxonium iodide 

Downstream Products

• 909406-73-1 6-oxaspiro[2.5]octane-1-carboxylic acid 

Relevant academic research and scientific papers

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Heterocyclic-substituted alkanamides as therapeutic compounds

Use of compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R1 and R2 have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

5-AMINO-4-HYDROXY-7- (IMIDAZO [1,2-A] PYRIDIN-6- YLMETHYL)-8-METHYL-NONAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION

Compounds of the general formula (I) or its salt or a compound in which one or more atoms are replaced by their stable, nonradio-active isotopes, in particular its pharmaceutically acceptable salt; in which X is -CH2-; R1 is a mono- to tetrasubstituted, mono- or bicyclic, unsaturated heterocyclic radical having 1 to 4 nitrogen atoms, R2 is C1-6alkyl or C3-6cycloalkyl; R3 is independently of one another H, C1-6alkyl, C1-6alkoxycarbonyl or C1-6alkanoyl; R4 is C2-6alkenyl, C1-6alkyl, unsubstituted or substituted aryl- C1-6alkyl or C3-8cycloalkyl; R5 is -Lm-R6; L is C1-6alkylene which is optionally substituted by 1-4 halogen, or a linker: formula (II) n = 0, 1 or 2; m = 0 or 1; R6 is a radical composed of 2 cyclic systems selected from bicyclo[x.y.z]alkyl, spiro[o.p]alkyl, mono- or bioxabicyclo[x.y.z]alkyl or mono- or bioxaspiro[o.p]alkyl, all of which may be substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6alkoxy- C1-6alkyl, hydroxy-C1-6alkyl or dialkylamino, or if m = 0: is also saturated C3-8heterocyclyl which comprises 1-2 oxygen atoms, substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6alkoxy- C1-6alkyl, hydroxy- C1-6alkyl or dialkylamino, or if m = 1: is also saturated C3-8heterocyclyl which comprises 1-2 oxygen atoms, optionally substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6-alkoxy-C1-6alkyl, hydroxy-C1-6alkyl or dialkylamino; have renin- inhibiting properties and can be used as medicines for the treatment of hypertension.

HETEROCYCLIC-SUBSTITUTED ALKANAMIDES USEFUL AS RENIN INHIBITORS

Compounds of the general formula (I) in which the meanings of the substituents R1 and R2 are as stated in claim 1, have renin-inhibiting properties and can be used as medicines.