909415-66-3Relevant academic research and scientific papers
Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors
Gopalsamy, Ariamala,Lim, Kitae,Ciszewski, Gregory,Park, Kaapjoo,Ellingboe, John W.,Bloom, Jonathan,Insaf, Shabana,Upeslacis, Janis,Mansour, Tarek S.,Krishnamurthy, Girija,Damarla, Murthy,Pyatski, Yelena,Ho, Douglas,Howe, Anita Y. M.,Orlowski, Mark,Feld, Boris,O'Connell, John
, p. 6603 - 6608 (2007/10/03)
A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano-[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.
