909418-94-6Relevant articles and documents
Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors
Ennis, Amanda F.,Fenton, benjamin A.,Hong, Jiyong,Kwak, Seung-Hwa,Lim, Won Young,Webster, caroline G.,Zhou, Pei,cho, Jae,cochrane, c. Skyler
, (2020)
The UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH is essential in lipid A biosynthesis and has emerged as a promising target for the development of novel antibiotics against multidrug-resistant Gram-negative pathogens. Recently, we reported the c
PYRROLE mTORC INHIBITORS AND USES THEREOF
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Paragraph 0405, (2020/01/12)
The present invention provides compounds, compositions thereof, and methods of using the same.
METHODS FOR FORMING ARYL CARBON-NITROGEN BONDS USING LIGHT AND PHOTOREACTORS USEFUL FOR CONDUCTING SUCH REACTIONS
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Paragraph 0099-0100; 0152-0153, (2019/11/22)
The disclosure relates to a method for forming aryl carbon-nitrogen bonds and to photoreactors useful in these and other light-driven reactions. The method comprises contacting an aryl halide with an amine in the presence of a Ni salt catalyst solution and an optional base, thereby forming a reaction mixture; exposing the reaction mixture to light under reaction condition sufficient to produce the aryl carbon-nitrogen bonds. In certain embodiments, the amine may be present in a molar excess to the aryl halide. In certain embodiments, the Ni salt catalyst solution includes a Ni(II) salt and a polar solvent, wherein the Ni(II) salt is dissolved in the polar solvent. In certain embodiments, the reactions conditions include holding the reaction mixture at between about room temperature and about 80° C. for between about 1 hour and about 20 hours such that at least about 50% yield is obtained.
