90946-69-3Relevant academic research and scientific papers
Hydrazones, ArNHN=CRCH2COX, from reactions of arylhydrazines, ArNHNH2, with 1,3-dicarbonyl compounds, RCOCH2COX(X = OR1 or NHPh): Crystal structures of (E)-4-O2NC 6H4NHN=CMeCH2CO2R1 (R1 = Me or Et) and (E)-PhNHN=CPhCH2CONHPh
De Lima, Geraldo M.,Wardell, James L.,Wardell, Solange M. S. V.
body text, p. 213 - 221 (2011/08/02)
The molecular and crystal structures of (E)-4-O2NC 6H4NHN=CMeCH2CO2R1 (4: R1 = Me; 5: R1 = Et) and (E)-PhNHN=CPhCH2CONHPh (6) are reported from data collected at 120(2) K. The major intermolecular interactions in both 4 and 5 involve the hydazonyl NH and the carbonyl oxygen, with formation of symmetric dimers. Due to 4 and 5 each having different sets of additional intermolecular interactions, different supramolecular arrays are produced: molecules of 4 are linked into a three-dimension structure, while zig-zag chains of molecules of 5 are obtained. Chains of molecules of 6, prepared from PhNHNH2 and PhCOCH2CONHPh, are obtained from intermolecular hydrogen bonds involving amido NH and carbonyl oxygen moieties. Further interactions, C-H-π(arene), C-H-O and π-π stacking interactions in 6 produces a three dimensional array. Compound 4 crystallizes in the triclinic space group P - 1 with a = 7.7027(2) A, b = 7.8103(2) A, c = 11.1761(3) A, α = 77.054(2)°, β = 79.425(2)°, γ = 81.097(2)°. Compound 5 crystallizes in the triclinic space group P - 1 with a = 5.6323(2)A, b = 9.9695(3)A, c = 11.0286(4)A, α = 91.859(2)°, β = 102.034(2)°, γ = 98.898(3)°. Compound 6 crystallizes in the monoclinic space group P21/c with a = 10.4255(8)A, b = 10.4255(8)A, c = 9.3368(5)A, β = 113.780(4) °.
Preparation and Antibacterial Activity of 3-Methyl-1-p-substituted Phenylpyrazole-5-thiol
Tagawa, Yoshinobu,Minami, Shin'ichi,Yoshida, Toshio,Tanaka, Keitaro,Sato, Shuji,Goto, Yoshinobu,Yamagata, Kenji
, p. 99 - 103 (2007/10/03)
3-Methyl-1-phenylpyrazole-5-thiol (3a) and its p-nitro- (5) and p-fluorophenyl (8) derivatives were prepared as potential antimicrobial agents in relatively good yields. Compounds 3a and 8 showed good antibacterial activities against MRSA, S. aureus, S. epidermidis, E. faecalis, E.faecium, and S. pyogenes. Moreover, compound 3a also showed a synergistic effect with some aminoglycosides.
