909784-57-2Relevant academic research and scientific papers
Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR
Finke, Paul E.,Meurer, Laura C.,Levorse, Dorothy A.,Mills, Sander G.,MacCoss, Malcolm,Sadowski, Sharon,Cascieri, Margaret A.,Tsao, Kwei-Lan,Chicchi, Gary G.,Metzger, Joseph M.,MacIntyre, D. Euan
, p. 4497 - 4503 (2007/10/03)
An initial investigation of the novel cyclopentane scaffold 6 afforded low nanomolar human NK1 antagonists having enhanced water solubility properties compared to morpholine 1. A synthesis of this cyclopentane scaffold, having three contiguous chiral cent
