909865-29-8

Basic information

• Product Name: [4-(3-fluoro-benzyloxy)-3-trifluoromethyl-phenyl]-(6-iodo-quinazolin-4-yl)-amine
• Synonyms: [4-(3-fluoro-benzyloxy)-3-trifluoromethyl-phenyl]-(6-iodo-quinazolin-4-yl)-amine
• CAS NO: 909865-29-8
• Molecular Weight: 539.271
• Mol File: 909865-29-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(3-fluoro-benzyloxy)-3-trifluoromethyl-phenyl]-(6-iodo-quinazolin-4-yl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(3-fluoro-benzyloxy)-3-trifluoromethyl-phenyl]-(6-iodo-quinazolin-4-yl)-amine(909865-29-8)
• EPA Substance Registry System: [4-(3-fluoro-benzyloxy)-3-trifluoromethyl-phenyl]-(6-iodo-quinazolin-4-yl)-amine(909865-29-8)

Safety Data

• Hazardous Substances Data: 909865-29-8(Hazardous Substances Data)

Upstream product

• 909865-28-7 4-((3-fluorobenzyl)oxy)-3-(trifluoromethyl)aniline 
• 98556-31-1 4-chloro-6-iodoquinazoline 
• 909865-27-6 1-(3-Fluoro-benzyloxy)-4-nitro-2-trifluoromethyl-benzene 
• 1548-61-4 4-nitro-2-(trifluoromethyl)phenol 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 

Downstream Products

• 307328-29-6 5-{4-[4-(3-fluoro-benzyloxy)-3-trifluoromethyl-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde 

Relevant articles and documents

Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series

Synthetic modifications on a 6-furanylquinazoline scaffold to optimize the dual ErbB-1/ErbB-2 tyrosine kinase inhibition afforded consistent SAR whereby a 4-(3-fluorobenzyloxy)-3-haloanilino provided the best enzyme potency and cellular selectivity. Changes made to the 6-furanyl group had little impact on the enzyme activity, but appeared to dramatically affect the cellular efficacy. The discovery of lapatinib emerged from this work.