910046-59-2Relevant academic research and scientific papers
Total synthesis and biological assessment of (-)-Exiguolide and analogues
Fuwa, Haruhiko,Suzuki, Takaya,Kubo, Hiroshi,Yamori, Takao,Sasaki, Makoto
scheme or table, p. 2678 - 2688 (2011/04/15)
We describe herein an enantioselective total synthesis of (-)-exiguolide, the natural enantiomer. The methylene bis(tetrahydropyran) substructure was efficiently synthesized by exploiting olefin cross-metathesis for the assembly of readily available acycl
Total synthesis of (-)-exiguolide
Fuwa, Haruhiko,Sasaki, Makoto
supporting information; experimental part, p. 584 - 587 (2010/05/17)
[Chemical equation presented] Total synthesis of (-)-exiguolide, the natural enantiomer, has been accomplished for the first time. The bis(tetrahydropyran) subunit was efficiently synthesized via consecutive olefin cross-metathesis/intramolecular oxa-conj
Synthetic studies toward bryostatin 1: preparation of a C1-C16 fragment by pyran annulation
Keck, Gary E.,Welch, Dennie S.,Poudel, Yam B.
, p. 8267 - 8270 (2007/10/03)
An expeditious assembly of a C1-C16 subunit of bryostatin 1 is described. A pyran annulation reaction was utilized to form the B-ring by reaction of a hydroxy-allylsilane with a fully elaborated A-ring subunit. This annulation proces
Synthetic studies toward the bryostatins: A substrate-controlled approach to the A-ring
Keck, Gary E.,Welch, Dennie S.,Vivian, Paige K.
, p. 3667 - 3670 (2007/10/03)
The synthesis of a C1-C13 A-ring subunit of bryostatin 1 is detailed. The key features of the approach include the convergent fragment assembly with a highly stereoselective construction of the C7-C8 bond indicated above.
