910046-72-9

Upstream product

• 112897-09-3 (3S)-1-{[t-butyl(diphenyl)silyl]oxy}hex-5-en-3-ol 
• 910046-59-2 tert-butyl-[(3S)-(4-methoxybenzyloxy)hex-5-enyloxy]diphenylsilane 

Downstream Products

• 916991-68-9 (2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester 
• 910046-77-4 3-(tert-butyl-diphenyl-silanyloxy)-7,8-dihydroxy-5-(4-methoxy-benzyloxy)-octanethioic acid S-tert-butyl ester 
• 910046-76-3 (3R,5S)-3-(tert-butyldiphenylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester 
• 910046-62-7 (3R,5S)-3-(tert-butyldiphenylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-oxoheptanethioic acid S-tert-butyl ester 
• 910046-60-5 (3R,5S)-3-hydroxy-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester 
• 322428-41-1 (S)-3-(4-methoxybenzyloxy)hex-5-enal 

Relevant academic research and scientific papers

Total synthesis of (-)-spinosyn A: Examination of structural features that govern the stereoselectivity of the key transannular Diels-Alder reaction

(Chemical Equation Presented) A study of elements of stereochemical control in transannular Diels-Alder reactions leading to the decahydro-as-indacene core of (-)-spinosyn A is described. Initial studies focused on macrocyclic pentaene 9, which includes C

Synthetic studies toward bryostatin 1: preparation of a C1-C16 fragment by pyran annulation

An expeditious assembly of a C1-C16 subunit of bryostatin 1 is described. A pyran annulation reaction was utilized to form the B-ring by reaction of a hydroxy-allylsilane with a fully elaborated A-ring subunit. This annulation proces

Synthetic studies toward the bryostatins: A substrate-controlled approach to the A-ring

The synthesis of a C1-C13 A-ring subunit of bryostatin 1 is detailed. The key features of the approach include the convergent fragment assembly with a highly stereoselective construction of the C7-C8 bond indicated above.