910138-86-2

Upstream product

• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 104010-72-2 (3aS,6aS)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one 
• 62681-68-9 (E)-1-(benzo[d][1,3]dioxol-5-yl)ethan-1-one oxime 
• 62681-67-8 2-(benzo[1,3]dioxol-5-yl)aziridine 
• 910138-81-7 C₃₁H₃₅NO₈S 
• 910138-82-8 C₂₅H₃₁NO₆ 
• 910138-80-6 C₂₁H₂₇NO₅Si 
• 910138-83-9 C₂₀H₂₃NO₅ 
• 910138-79-3 C₁₇H₁₇NO₅ 
• 910138-78-2 6-[2-(benzo[1,3]dioxol-5-yl)aziridin-1-yl]-2,2-dimethyl-3a,6a-dihydrocyclopenta[1,3]dioxol-4-one 
• 910138-75-9 (+)-6-chloro-2,2-dimethyl-5-(phenylselenyl)tetrahydrocyclopenta[1,3]dioxol-4-ol 
• 910138-76-0 (-)-6-chloro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol 
• 1040271-76-8 6-chloro-2,2-dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one 
• 910138-85-1 C₂₈H₂₉NO₇ 

Downstream Products

• 910138-88-4 C₃₀H₃₁NO₉ 
• 36804-95-2 deoxyharringtonine 
• 38750-57-1 (-)-Cephalotaxinone 
• 910138-89-5 C₂₅H₂₃NO₆ 

Relevant academic research and scientific papers

Strain-release rearrangement of N-vinyl-2-arylaziridines. Total synthesis of the anti-leukemia alkaloid (-)-deoxyharringtonine

Deoxyharringtonine (1) is among the most potent of the anti-leukemia alkaloids isolated from the Cephalotaxus genus. A convergent total synthesis of (-)-1 is reported, involving novel synthetic methods and strategies that include (1) the strain-release rearrangement of N-aryl-2-vinylaziridines for [3]benzazepine synthesis, (2) a vinylogous amide acylation-cycloaddition cascade for spiro-pyrrolidine construction, and (3) efficient acylation of the cephalotaxine core by α-(β-lactone)carboxylic acid derivatives to access the biologically active cephalotaxus esters. These innovations should allow rapid access not only to other Cephalotaxus alkaloids but also to non-natural analogues of potential therapeutic utility. Copyright