62681-68-9

Basic information

• Product Name: 1-benzo[1,3]dioxol-5-yl-ethanone oxime
• Synonyms: 1-benzo[1,3]dioxol-5-yl-ethanone oxime
• CAS NO: 62681-68-9
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17266
• EINECS: -0
• Mol File: 62681-68-9.mol
• Article Data: 26

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzo[1,3]dioxol-5-yl-ethanone oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzo[1,3]dioxol-5-yl-ethanone oxime(62681-68-9)
• EPA Substance Registry System: 1-benzo[1,3]dioxol-5-yl-ethanone oxime(62681-68-9)

Safety Data

• Hazardous Substances Data: 62681-68-9(Hazardous Substances Data)

Usage

General Description

1-benzo[1,3]dioxol-5-yl-ethanone oxime, also known as benzodioxolylacetoxime, is a chemical compound with the molecular formula C9H9NO3. 1-benzo[1,3]dioxol-5-yl-ethanone oxime is commonly used as a reagent in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. It is an oxime derivative of 1-benzo[1,3]dioxole-5-carbaldehyde and is typically used as a protecting group for carbonyl compounds. 1-benzo[1,3]dioxol-5-yl-ethanone oxime has potential applications in drug discovery and development, as well as in the creation of new chemical entities. However, it is important to handle this compound with care, as it may pose certain hazards if not properly managed in a laboratory setting.

Upstream product

• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 2373-80-0 3,4-methylenedioxy-trans-cinnamic acid 
• 274-09-9 Methylenedioxybenzene 

Downstream Products

• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 921936-94-9 C₂₁H₁₈NO₃P 
• 36804-95-2 deoxyharringtonine 
• 38750-57-1 (-)-Cephalotaxinone 
• 1040272-14-7 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate 
• 1040272-38-5 (1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-4-oxooxetane-2-carboxylate 
• 910138-87-3 C₃₀H₃₃NO₉ 
• 1040271-64-4 C₂₈H₂₅NO₈ 
• 1040271-86-0 C₂₈H₂₉NO₇ 
• 910138-88-4 C₃₀H₃₁NO₉ 
• 910138-81-7 C₃₁H₃₅NO₈S 
• 910138-85-1 C₂₈H₂₉NO₇ 
• 910138-89-5 C₂₅H₂₃NO₆ 
• 13067-19-1 3,4-methylenedioxyacetanilide 

Relevant articles and documents

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.

Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides

Disclosed herein is an efficient Ag-catalyzed [4 + 1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance.

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