910209-21-1

Basic information

• Product Name: CYCLOPROPANESULFINIC ACID, SODIUM SALT
• Synonyms: CYCLOPROPANESULFINIC ACID, SODIUM SALT;Sodium Cyclopropanesulfinate
• CAS NO: 910209-21-1
• Molecular Formula: C₃H₅O₂S*Na
• Molecular Weight: 128.13
• Mol File: 910209-21-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 245-248°C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: CYCLOPROPANESULFINIC ACID, SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPROPANESULFINIC ACID, SODIUM SALT(910209-21-1)
• EPA Substance Registry System: CYCLOPROPANESULFINIC ACID, SODIUM SALT(910209-21-1)

Safety Data

• Hazardous Substances Data: 910209-21-1(Hazardous Substances Data)

Usage

Uses

Sodium Cyclopropanesulfinate is a general chemical reagent used in the synthesis of AMG 232 (A576560), a potent MDM2-P53 inhibitor for use as an anti-tumor agent.

InChI:InChI=1/C3H6O2S.Na/c4-6(5)3-1-2-3;/h3H,1-2H2,(H,4,5);/q;+1/p-1

Upstream product

• 139631-62-2 cyclopropanesulfonyl chloride 

Downstream Products

• 1147558-13-1 4-(cyclopropylsulfonyl)aniline 
• 1354558-30-7 4-(cyclopropanesulfonyl)benzaldehyde 

Relevant articles and documents

Visible-Light-Induced, Palladium-Catalyzed 1,4-Difunctionalization of 1,3-Dienes with Bromodifluoroacetamides

A highly modular 1,4-difunctionalization of 1,3-dienes with bromodifluoroacetamides and sulfinates/amines through a photoinduced palladium-catalyzed radical relay process is described herein. This developed protocol offers a facile and general route to ac

Electrochemistry Enabled Nickel-Catalyzed Selective C?S Bond Coupling Reaction

This work describes an electrochemical enabled nickel-catalyzed chemoselective C?S bond coupling protocol for the production of aryl sulfides and sulfones. By simply switching the nickel catalysts and electrodes, this electrochemical C?S bond coupling has demonstrated excellent redox activity, scalability and sustainability. Furthermore, the mechanism for this electrochemical cross-coupling reaction has been investigated.

Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol

Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant molecules. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy.