910212-29-2Relevant academic research and scientific papers
Synthesis and pharmacological study of novel pyrido-quinazolone analogues as anti-fungal, antibacterial, and anticancer agents
Tiwari, Anjani K.,Mishra,Bajpai, Aruna,Mishra, Pushpa,Sharma,Pandey,Singh, Vinay Kumar
, p. 4581 - 4585 (2006)
A versatile method for novel pyrido-quinazolones was described here and tested for anti-fungal, antibacterial, and anticancerous activities. These synthesized compounds were characterized on the basis of spectroscopic techniques and evaluated for specific radiopharmaceuticals. Preliminary radiolabeling results with 99mTc and biological evaluation studies showed promising results for further evaluation in vivo. The efficiency of labeling was more than 98% and complexes were stable for about 18 h at 25 °C in the presence of serum.
Synthesis and in vitro evaluation of N-Aryl pyrido-quinazolines derivatives as potent epidermal growth factor receptor inhibitors
Singh, Vinay K.,Sharma, Himanshu,Singh, Sanjay K.,Gangwar, Lakshmi
, p. 119 - 124 (2013/07/26)
A series of pyrido-quinazolines have been synthesised, characterized, and tested for their in vitro epidermal growth factor receptor (EGFR) tyrosine kinase inhibitory activity. The compounds were prepared from Alkylideno/arylideno-bis-ureas. Their final structure of the compounds was elucidated on the basis of spectral studies (IR, 1H NMR, FT-IR, and EI-MS). The cellular EGFR internalization response of selected compounds was evaluated using HeLa cells. Most of the synthesized compounds displayed potent EGFR-TK inhibitory activity and structurally halogenated derivatives had a pronounced effect in inhibiting EGFR internalization.
Synthesis, antibacterial and antifungal activity of some new pyrido quinazolones
Singh,Pandey
, p. 2745 - 2748 (2007/10/03)
Alkylideno/arylideno bis ureas 1 synthesized by ureido-alkylation in the presence of alcohols-which on treatment with p-aminobenzoic acid results in 4-aryl-6-carboxylato-1,2,3,4-tetrahydroquinazolines 2. Reaction of 2 with benzoin in presence of polyphosphoric acid yields 4-aryl-8,9-diphenyl-1,4 dihydro-3H, 7-oxo-1,3-diaza anthracene-2,6-dione 3. Condensation of 3 with aromatic primary amine affords N-aryl-8,9-diphenyl (-2-oxopyrido [g]-4-aryl-2-oxo-1,3-dihydro quinazolines 4. The new compound 4 has been screened for their antibacterial and antifungal activities.
