910221-53-3Relevant academic research and scientific papers
New Derivatives of Thiosemicarbazide and 1,2,4-Triazoline-5-thione with Potential Antimicrobial Activity
Wujec, Monika,Kosikowska, Urszula,Siwek, Agata,Malm, Anna
experimental part, p. 559 - 567 (2009/10/15)
In the reaction of the hydrazide of (4-nitroimidazol-1-yl)acetic acid 1 with isothiocyanates, the respective thiosemicarbazide derivatives 2-6 were obtained. Further cyclization with 2% NaOH led to the formation of 3-[(4-nitroimidazol-1-yl)-methyl]-4-substituted-1,2,4-triazoline-5-thiones 7-11. The structures of all new products were confirmed by analytical and spectroscopic methods. Six compounds 2-5, 8, and 10 were screened for their in vitro activity against some species of aerobic bacteria and fungi. Compound 3 appears to be a promising precursor of agents with antibacterial activity against Micrococcus luteus.
