910221-59-9Relevant academic research and scientific papers
Synthesis and anti-helicobacter pylori activity of (4-nitro-1- imidazolylmethyl)-1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles
Tafti, Asal Fallah,Akbarzadeh, Tahmineh,Saniee, Parastoo,Siavoshi, Farideh,Shafiee, Abbas,Foroumadi, Alireza
experimental part, p. 307 - 316 (2011/12/16)
A series of [(4-nitro-1 H-imidazol-1-yl) methyl]-1,2,4-triazoles and 1,3,4-thiadiazoles were prepared and evaluated for their activity against sensitive and resistant H. pylori strains. Study of the structure-activity relationship of these series of compounds indicated that the type of nitroimidazole moiety and the pendent group on the heteroaryl analog dramatically impact the anti-H. pylori activity. In triazole series, compound 5d, containing a 4-methyl phenyl group on the triazole ring, was the most potent compound tested against both metronidazole-sensitive and-resistant strains at a concentration of 8 μg. TUeBITAK.
