910240-95-8

Upstream product

• 54413-84-2 methyl 2-iodo-4-methoxybenzoate 
• 371-40-4 4-fluoroaniline 
• 216768-18-2 4-methoxy-2-(trifluoro-methanesulfonyloxy)-benzoic acid methyl ester 

Downstream Products

• 910240-96-9 methyl 2-(4-fluoroanilino)-4-hydroxybenzoate 

Relevant academic research and scientific papers

A convenient procedure for parallel ester hydrolysis

The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.

NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF

The anthranilic acid derivative or the salt thereof represented by the general formula wherein R1 and R2 are hydrogen atom, or the like; R3 is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; R4 is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; X1 is an alkylene or alkenylene group which may be substituted or a bond; X2 is the general formula -X3-X4- or -X4-X3-, wherein X3 is a sulfur atom, an imino group or a bond, or the like; X4 means an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP-13 production inhibitory effect.