910249-98-8Relevant academic research and scientific papers
Development of first photoresponsive prodrug of paclitaxel
Skwarczynski, Mariusz,Noguchi, Mayo,Hirota, Shun,Sohma, Youhei,Kimura, Tooru,Hayashi, Yoshio,Kiso, Yoshiaki
, p. 4492 - 4496 (2006)
A prodrug of paclitaxel which has a coumarin derivative conjugated to the amino acid moiety of isotaxel (O-acyl isoform of paclitaxel) has been synthesized. The prodrug was selectively converted to isotaxel by visible light irradiation (430 nm) with the c
