133524-70-6

Basic information

• Product Name: Benzenepropanoic acid, b-amino-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, (aR,bS)-
• Synonyms: Benzenepropanoicacid, b-amino-a-hydroxy-,6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-;7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.;3'-N-Debenzoylpaclitaxel; Baccatin III 13-[b(S)-amino-a(R)-hydroxyphenylpropionate]; N-Debenzoylpaclitaxel; N-Debenzoyltaxol;N-Debenzoyltaxol A
• CAS NO: 133524-70-6
• Molecular Formula: C40H47 N O13
• Molecular Weight: 749.812
• Mol File: 133524-70-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-amino-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, (aR,bS)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-amino-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, (aR,bS)-(133524-70-6)
• EPA Substance Registry System: Benzenepropanoic acid, b-amino-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, (aR,bS)-(133524-70-6)

Safety Data

• Hazardous Substances Data: 133524-70-6(Hazardous Substances Data)

Upstream product

• 125354-16-7 10-acetyldocetaxel 
• 32981-86-5 10-deacetylbaccatin III 
• 27548-93-2 baccatin III 
• 143615-03-6 (4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid 
• 863203-46-7 C₄₀H₄₆N₂O₁₄ 
• 71610-00-9 cephalomannine 
• 160237-83-2 7-(triethylsilyl)baccatin III 13--(2'R,3'S)-3'-phenylisoserinate> 
• 155399-25-0 (3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone 
• 132127-30-1 (3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-phenylazetidin-2-one 
• 232920-80-8 C₆₀H₈₉NO₁₅Si₂ 
• 172213-23-9 (3R,4S)-1-benzoyl-3-triisopropylsilyloxy-4-phenylazetidin-2-one 
• 115437-21-3 7-(triethylsilyl)baccatin III 
• 144465-78-1 1-(4-Methoxyphenyl)-3-triisopropylsilyloxy-4-phenyl-2-azetidinone 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 

Downstream Products

• 153695-19-3 N-(4-azidobenzoyl)-N-debenzoyltaxol 
• 143842-96-0 baccatin III 13- 
• 173101-56-9 C₄₈H₅₃NO₁₄ 
• 153415-45-3 taxuyunnansine 
• 1129540-33-5 C₄₇H₄₆⁽²⁾H₅NO₁₄ 
• 1315376-87-4 C₅₃H₅₈⁽²⁾H₅NO₁₃Si 
• 1315376-88-5 C₅₃H₆₀⁽²⁾H₅NO₁₅Si 
• 1315376-89-6 C₅₃H₆₀⁽²⁾H₅NO₁₅Si 
• 1315376-90-9 C₄₇H₄₆⁽²⁾H₅NO₁₅ 
• 1315376-85-2 C₅₃H₆₀⁽²⁾H₅NO₁₄Si 
• 1315376-86-3 C₅₄H₅₉⁽²⁾H₅F₃NO₁₆SSi 
• 1382190-40-0 (1S,2S,4S,9S,10S,15S,3R,7R,12R)-4,12-diacetyloxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-2-phenylcarbonyloxy-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl (3S,2R)-2-hydroxy-3-{4-[N-(2-[2-hydroxy-1-(hydroxymethyl)ethoxy]-1-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}ethyl)carbamoyl]butanoylamino}-3-phenylpropanoate 
• 1382190-46-6 (1S,2S,4S,9S,10S,15S,3R,7R,12R)-4,12-diacetyloxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-2-phenylcarbonyloxy-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl (3S,2R)-2-hydroxy-3-[4-(N-{2-(2-[2-hydroxy-1-(hydroxymethyl)ethoxy]-1-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}ethoxy)-1-[(2-[2-hydroxy-1-(hydroxymethyl)ethoxy]-1-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}ethoxy)methyl]ethyl}carbamoyl)butanoylamino]-3-phenylpropanoate 

Relevant articles and documents

Method for synthesizing paclitaxel from cephalomannine (by machine translation)

The method comprises the following steps: (≥ 9997%) bases as a raw material, N - Butene keys on the side chains of the bases 13 through low-temperature acid hydrolysis; and protecting; and NH (NH-7 ') in the side chains 2, 13 -'. 2 The method has the advantages of mild 7 and 2 controllable reaction conditions, low cost, high yield, high product purity, low impurity content, and suitability for industrial production and market popularization and application 99%. the method comprises the following steps: synthesizing and converting paclitaxel crude product through crystallization, carrying out one-time column chromatography and primary recrystallization purification to obtain paclitaxel. (by machine translation)

Synthesis of deuterium-labelled paclitaxel and its hydroxyl metabolite

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A PROCESS FOR THE PURIFICATION OF 10-DEACETYLBACCATINE III FROM 10-DE ACET YL-2- DEBENZOYL-2-PENTENOYLBACCATINE III

A process for the preparation of 10-deacetyl-7,10-bis- trichloroacetylbaccatine III with HPLC purity higher than 99% and free from 2-debenzoyl-2-pentenoylbaccatine III by purification of 10-deacetyl-7,10-bis- trichloroacetylbaccatineIII followed by alkaline hydrolysis of the protecting groups in position 7 and 10.