91027-06-4Relevant academic research and scientific papers
REGIOSELECTIVE ADDITION OF HYDRAZINES TO ALLENYLACETYLENES - CONVENIENT ROUTE TO 3(5)-METHYL-5(3)-SUBSTITUTED PYRAZOLES
Khrimyan, A. P.,Karapetyan, A. V.,Badanyan, Sh. O.
, p. 189 - 196 (2007/10/02)
It is shown that hydrazine hydrate, methylhydrazine, and phenylhydrazine add smoothly and regioselectively to allenylacetylenes to give 3(5)-methyl-5(3)-substituted pyrazoles.In addition to the principal process, isomerization of allenylacetylenes to methyldiacetylenes, and the degree of which depends on the structure of the substrate, is observed in the reaction of methylhydrazine in an aqueous alcohol medium.
