910303-09-2Relevant academic research and scientific papers
Synthesis and radioiodination of some 9-aminoacridine derivatives for potential use in radionuclide therapy
Ghirmai, Senait,Mume, Eskender,Lundqvist, Hans,Tolmachev, Vladimir,Sjoeberg, Stefan
, p. 855 - 871 (2007/10/03)
Three derivatives of the DNA intercalating compound 9-aminoacridine, were prepared and radioiodinated for biological experiments. The compounds are the stannyl derivatives 3-{4-[3-(acridin-9-ylamino)-propoxy]-3-trimethylstannyl- phenyl}-propionic acid and acridin-9-yl-{3-[4-(2-amino-ethyl)-2- trimethylstannyl-phenoxy]-propyl}-amine which were synthesized from the corresponding iodo derivatives by palladium catalyzed reactions, and 4-[2-(acridin-9-ylamino)-ethyl]-phenol. The two stannylated compounds and the phenol were used as precursors for radioiodination and were labeled with 125I using chloramine-T as an oxidant achieving high-to-excellent yields. Copyright
