910315-75-2Relevant academic research and scientific papers
Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction
Giovannoni, Maria Paola,Vergelli, Claudia,Biancalani, Claudio,Cesari, Nicoletta,Graziano, Alessia,Biagini, Pierfrancesco,Gracia, Jordi,Gavaldà, Amadeu,Dal Piaz, Vittorio
, p. 5363 - 5371 (2007/10/03)
Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones and their analogues, potentially useful for the treatment of erectile dysfunction, were synthesized and evaluated as inhibitors of phosphodiesterase 5 (PDE5). Several compounds showed IC50
