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91037-65-9

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91037-65-9 Usage

Uses

Different sources of media describe the Uses of 91037-65-9 differently. You can refer to the following data:
1. Supports fibroblast attachment
2. Arg-Gly-Asp-Ser has been used:to study its effects on cell attachment in ratsto analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptorto pretreat the cells, to assess the role of integrin in the cell attachment processto test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)

General Description

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor ?1 (TGF?1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstratedto mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages

Biological Activity

rgds peptide contains the rgd motif which is an antagonist of integrin [1, 2].integrins are cell-surface receptors that recognize rgd motifs present in various extracellular matrix proteins such as fibronectin, vitronectin, laminin, fibrinogen, von willebrand factor, osteopontin, thrombospondin, and collagen as well as in disintegrins. integrins activation triggers different signals regulating cell adhesion, migration, survival, apoptosis as well as processes such as angiogenesis, thrombosis and osteoporosis [1].in sk-mel-110 cells, rgds at 500 μg/ml significantly inhibited melanoma cells proliferation induced by human fibroblast growth factor-2 (fgf-2). furthermore, rgds treatment (48 h, 500 μg/ml) increased the percentage of cells in sub-g1-phase from 3% (with fgf-2 alone) to 13.2% (with fgf-2 and rgds), indicating that rgds might induce apoptosis in melanoma cells, in the presence of fgf-2 [1].in a guinea pig model of allergic asthma, topical treatment of the airways with intranasally instilled rgds (2.5 mm, 200 μl) attenuated allergen-induced airway smooth muscle hyperplasia and hypercontractility as well as increased pulmonary expression of smooth muscle myosin heavy chain and the proliferative marker proliferating cell nuclear antigen [2].[1]. aguzzi m s, fortugno p, giampietri c, et al. intracellular targets of rgds peptide in melanoma cells. molecular cancer, 2010, 9(84): 1-10.[2]. dekkers b g, bos i s, gosens r, et al. the integrin-blocking peptide rgds inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. american journal of respiratory and critical care medicine, 2010, 181(6): 556-565.

Check Digit Verification of cas no

The CAS Registry Mumber 91037-65-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,0,3 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 91037-65:
(7*9)+(6*1)+(5*0)+(4*3)+(3*7)+(2*6)+(1*5)=119
119 % 10 = 9
So 91037-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H27N7O8/c16-7(2-1-3-19-15(17)18)12(27)20-5-10(24)21-8(4-11(25)26)13(28)22-9(6-23)14(29)30/h7-9,23H,1-6,16H2,(H,20,27)(H,21,24)(H,22,28)(H,25,26)(H,29,30)(H4,17,18,19)

91037-65-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name RGDS peptide

1.2 Other means of identification

Product number -
Other names RGDS/ARG-GLY-ASP-SER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:91037-65-9 SDS

91037-65-9Downstream Products

91037-65-9Relevant articles and documents

RGD-peptides modifying dexamethasone: to enhance the anti-inflammatory efficacy and limit the risk of osteoporosis

Yu, Hualong,Mei, Shenghui,Zhao, Li,Zhao, Ming,Wang, Yuji,Zhu, Haimei,Wang, Yaonan,Wu, Jianhui,Cui, Chunying,Xu, Wenyun,Peng, Shiqi

supporting information, p. 1345 - 1351 (2015/07/15)

Dexamethasone (Dex) is one of the most effective anti-inflammatory glucocorticoids, while the side effect, osteoporosis seriously limits its clinical use. Cell adhesion is involved in the onset of inflammation and osteoporosis, and RGD-peptides are well k

Dual-acting agents that possess free radical scavenging and antithrombotic activities: Design, synthesis, and evaluation of phenolic tetrahydro-β-carboline RGD peptide conjugates

Bi, Wei,Bi, Lanrong,Cai, Jianhui,Liu, Sanguang,Peng, Shiqi,Fischer, Nicholas O.,Tok, Jeffrey B.-H.,Wang, Guohua

, p. 4523 - 4527 (2007/10/03)

A new approach to construct a single dual-acting agent is described. Compounds 6a-c are potent free radical scavengers as demonstrated by the EC50 values in PC12 cell survival assay in term of NO, H2O2, and {radical dot}OH scavenging activity. The Ach-induced vaso-relaxation assay further confirms the potent NO scavenging activity of compounds 6a-c. In addition, 6a-c are efficacious in a rat arterial thrombosis, and are active in ADP- or PAF-induced in vitro platelet aggregation assay, suggesting that compounds 6a-c also possess anti-thrombotic activities. Since both free radical and thrombogenesis are important risk factors in myocardial ischemic/reperfusion injuries, these dual-acting agents having both free radical scavenging and antithrombolic activities may potentially be beneficial toward their treatment.

Fibrinogen-coated particles for therapeutic use

-

, (2008/06/13)

The invention provides a particle comprising fibrinogen bound on the surface of an albumin matrix, wherein said particle is capable of coaggregation with platelet, and of aggregation in a solution containing soluble fibrinogen at a concentration of soluble fibrinogen not capable by it self of formation of a clot upon activation by thrombin.

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