792169-28-9

Upstream product

• 171519-62-3 Boc-Asp(OcHex)-Ser(Bzl)-OBzl 
• 67321-05-5 Ser(Bzl)-OBzl 
• 69871-79-0 (S)-benzyl 3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)propanoate 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 73821-95-1 Boc-Asp(O-cyclohexyl)-OH 
• 100-39-0 benzyl bromide 

Downstream Products

• 199166-37-5 N-(2-benzyloxy-1-benzyloxycarbonyl-ethyl)-3-(2-tert-butoxycarbonylamino-acetylamino)-succinamic acid cyclohexyl ester 
• 199166-39-7 Boc-Arg(Tos)-Gly-Asp(OcHex)-Ser(Bzl)-OBzl 
• 91037-65-9 H-Arg-Gly-Asp-Ser-OH 
• 788804-09-1 (S)-3-(2-Amino-acetylamino)-N-((S)-2-benzyloxy-1-benzyloxycarbonyl-ethyl)-succinamic acid cyclohexyl ester 

Relevant academic research and scientific papers

Dual-acting agents that possess free radical scavenging and antithrombotic activities: Design, synthesis, and evaluation of phenolic tetrahydro-β-carboline RGD peptide conjugates

A new approach to construct a single dual-acting agent is described. Compounds 6a-c are potent free radical scavengers as demonstrated by the EC50 values in PC12 cell survival assay in term of NO, H2O2, and {radical dot}OH scavenging activity. The Ach-induced vaso-relaxation assay further confirms the potent NO scavenging activity of compounds 6a-c. In addition, 6a-c are efficacious in a rat arterial thrombosis, and are active in ADP- or PAF-induced in vitro platelet aggregation assay, suggesting that compounds 6a-c also possess anti-thrombotic activities. Since both free radical and thrombogenesis are important risk factors in myocardial ischemic/reperfusion injuries, these dual-acting agents having both free radical scavenging and antithrombolic activities may potentially be beneficial toward their treatment.

Application of a unique automated synthesis system for solution-phase peptide synthesis

An automated synthesis system, which is suitable for repetitive syntheses using similar reaction procedures, was used to synthesize systematically a library of all possible dipeptides (25) and tripeptides (125) from 5 protected amino acids. The apparatus has also been applied to the automated synthesis of 10 fragment tripeptide derivatives that are constituents of the hormone PACAP-27. The measured molecular optical rotation values of the library of 125 tripeptides were found to correlate well with calculated values obtained by summation of the molecular optical rotation values for the constituent amino acids.