910378-40-4Relevant academic research and scientific papers
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
Chu, Lin,Armstrong, Helen M.,Chang, Linda L.,Cheng, Amy F.,Colwell, Lawrence,Cui, Jisong,Evans, Jilly,Galka, Amy,Goulet, Mark T.,Hayes, Nancy,Lo, Jane,Menke, John,Ok, Hyun O.,Ondeyka, Debra L.,Patel, Minal,Quaker, Grace M.,Sings, Heather,Witkin, Stephanie L.,Zhao, Annie,Ujjainwalla, Feroze
, p. 4133 - 4138 (2012/07/03)
A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups.
DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
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Page/Page column 69-70, (2008/06/13)
The instant invention provides compounds of Formula (I) which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
