910483-02-2

Usage

Molecular structure

Contains a quinazolinone ring with a chlorine atom at the 6th position, an ethyl group at the 4th position, a trifluoroethyl group at the 3rd position, and a 4-fluorophenyl group at the 4th position

Potential use

May be used in pharmaceutical research as a potential drug candidate

Unique structural features

Contains a complex molecular structure with multiple functional groups

Synthesis and characterization

Research interest in the field of organic chemistry and drug discovery

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 784-40-7 (2-amino-5-chlorophenyl)(4-fluorophenyl)methanone 
• 910484-13-8 6-chloro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one 

Relevant academic research and scientific papers

Discovery of 4,4-disubstituted quinazolin-2-ones as T-type calcium channel antagonists

A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 by modifications of the 3- and 4-positions of the quinazolinone ring afforded potent

QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS

The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.