784-40-7

Usage

Uses

Used in Organic Synthesis:
(2-AMINO-5-CHLOROPHENYL)(4-FLUOROPHENYL)METHANONE is used as a building block in organic synthesis for the creation of various chemical compounds. Its unique structure with both amino and chloro substituents allows for versatile reactions and the formation of a wide range of molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2-AMINO-5-CHLOROPHENYL)(4-FLUOROPHENYL)METHANONE is used as a key intermediate in the development of new drugs. Its ability to be modified and combined with other molecules makes it a valuable component in the synthesis of potential therapeutic agents.

Upstream product

• 34999-46-7 N-(2-(4-fluorobenzoyl)-4-chlorophenyl)acetamide 
• 403-43-0 4-fluorobenzoyl chloride 
• 106-47-8 4-chloro-aniline 
• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 352-13-6 4-flourophenylmagnesium bromide 
• 869365-90-2 N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide 

Downstream Products

• 16771-51-0 (2-amino-5-chloro-phenyl)-(4-fluoro-phenyl)-methanol 
• 138772-90-4 <(S)->2-amino-5-chloro-4'-fluorobenzhydrol 
• 2647-49-6 2-Bromacetylamino-5-chlor-4'-fluor-benzophenon 
• 138772-91-5 <(S)->N-isonicotinoyl-2-amino-5-chloro-4'-fluorobenzhydrol 
• 35001-98-0 6-chloro-4-(4-fluoro-phenyl)-2-methylsulfanyl-4H-benzo[d][1,3]thiazine 
• 35001-86-6 6-chloro-4-(4-fluoro-phenyl)-1,4-dihydro-benzo[d][1,3]thiazine-2-thione 
• 910484-12-7 N-(4-chloro-2-(4-fluorobenzoyl)phenyl)-1H-imidazole-1-carboxamide 
• 1001326-43-7 3,4-dichloro-N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-benzenesulfonamide 
• 910484-13-8 6-chloro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one 
• 910484-25-2 [14C]-TTA-Q₃ 
• 1213235-34-7 TTA-Q₅ 
• 1361498-00-1 ethyl 6-chloro-4-(4-fluorophenyl)-1,2-dihydro-2-oxoquinoline-3-carboxylate 
• 118314-81-1 (E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-methyl-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester 

Relevant academic research and scientific papers

Quinolinones as Inhibitors of Translation Initiation Complex

Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.

Synthesis of 2-aminobenzophenone derivatives and their anticancer activity

A number of 2-aminobenzophenones have been synthesized by acylation of para-chloroaniline with different 2-, 3-, 4-chloro-or fluorobenzoyl chloride in solid state via the Friedel-Crafts reaction. Synthesized compounds were characterized by 1H and 13C NMR, Fourier transform-infrared, ultraviolet-visible spectroscopy, mass spectrometry, and elemental analysis. Evaluation of biological activity in vitro showed that the selected compounds 9, 10, and 13 have potential anticancer activity. The presence of one chlorine atom in the second aromatic ring of the benzophenone molecule makes it more active.

QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS

The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is al

QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS

The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

Compounds and methods for inhibiting mitotic progression

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat

Synthesis and spectral properties of 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines

A series of twelve new 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines, which have possible pharmacological properties has been obtained. The synthesis was carried out following six steps. The structure of all products was corroborated by ir, 1H nmr, 13C nmr and ms. In addition for the compound 2-(o-chloroaminophenyl)-3H-5-(o-fluorophenyl)-7-chloro-1,4-benzodiazepine 7, its structure was confirmed by X-ray diffraction.

6-(((SUBSTITUTED)QUINOLINYL)ETHYL)-AND ETHENYL)TETRAHYDRO-4-HYDROXYPYRAN-2-ONE INHIBITORS OF CHOLESTEROL BIOSYNTHESIS

Certain trans-6-(substituted)quinolinyl!ethyl!-and ethenyl!tetrahydro-4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA re