910484-74-1

Basic information

• Product Name: (S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol
• Synonyms: (S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol
• CAS NO: 910484-74-1
• Molecular Weight: 284.303
• Mol File: 910484-74-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol(910484-74-1)
• EPA Substance Registry System: (S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol(910484-74-1)

Safety Data

• Hazardous Substances Data: 910484-74-1(Hazardous Substances Data)

Upstream product

• 420-90-6 3-bromo-3,3-difluropropene 
• 130796-32-6 (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde 
• 124649-67-8 methyl (2S,3R)-3-phenyl-2,3-dihydroxypropanoate 
• 103-26-4 Methyl cinnamate 
• 214194-15-7 (4S,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 133520-57-7 (4S,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane 

Downstream Products

• 910484-77-4 acrylic acid (S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-enyl ester 
• 910484-79-6 (S)-6-{(4S,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-5,5-difluoro-5,6-dihydropyran-2-one 

Relevant articles and documents

Stereocontrolled synthesis of gem-difluoromethylenated goniodiols and goniothalamin epoxides based on ring-closing metathesis

An efficient and general method to stereoselectively synthesize gem-difluoromethylenated goniodiols and goniothalamin epoxides has been developed. The introduction of a gem-difluoromethyl-containing group was achieved by the reaction of aldehydes with 3-bromo-3,3-difluoropropene in the presence of indium. The gem-difluoromethylenated α,β-unsaturated- δ-lactone moiety was constructed through the ring-closing metathesis of highly electron-deficient gew-difluoromethylenated acryloyl esters by Grubbs' II catalyst in toluene at reflux. Georg Thieme Verlag Stuttgart.