133520-57-7

Upstream product

• 145376-18-7 (4R,5R)-2,2-dimethyl-4-phenyl-5-vinyl-1,3-dioxolane 
• 133521-66-1 (4S,5R)-Ethyl 2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate 
• 214194-15-7 (4S,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 81691-59-0 (2RS,3RS)-2,3-dihydroxy-3-phenyl-propionic acid methyl ester 
• 5695-95-4 (2RS,3SR)-2,3-dihydroxy-3-phenyl-propionic acid 
• 81691-58-9 methyl DL-threo-3-phenyl-2,3-O-isopropylideneglycerate 
• 140-10-3 (E)-3-phenylacrylic acid 
• 133421-01-9 3-(Dimethylthexylsiloxy)-3-phenyl-2-(trimethylsiloxy)propannitril 
• 56503-11-8 ethyl (3R)-2,3-dihydroxy-3-phenylpropanoate 
• 145332-90-7 (2R,3S)-2-methanol-3-<2-((1-phenyl-1-methoxymethoxy)but-3-en)yloxy>-3,4,5,6-tetrahydro-2H-pyran 
• 145376-17-6 (1R,2R)-1-phenyl-but-3-ene-1,2-diol 
• 108741-14-6 (2R,3S)-ethyl 2,3-dihydroxy-3-phenylpropanoate 
• 103-26-4 methyl cinnamate 
• 283179-43-1 (1R,2S,3R)-1-acetoxy-1-phenylsulfonyl-3-phenyl-2,3-propandiol 

Downstream Products

• 171736-33-7 Methanesulfonic acid (4R,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-ylmethyl ester 
• 130796-32-6 (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde 
• 104713-12-4 (1S)-1-phenylprop-2-en-1-ol 
• 215544-07-3 (4S,5R)-4-Iodomethyl-2,2-dimethyl-5-phenyl-[1,3]dioxolane 
• 81691-62-5 9-(RS)-threo-(2,3-O-isopropylidene-3-phenyl-2,3-dihydroxypropyl)adenine 
• 81691-63-6 9-(RS)-threo-(2-phenyl-2,3-dihydroxypropyl)adenine 
• 81691-61-4 Toluene-4-sulfonic acid (4S,5S)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-ylmethyl ester 

Relevant academic research and scientific papers

SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING A PSYCHIATRIC DISORDER

The present invention relates to a pharmaceutical composition for treating and/or alleviating a psychiatric disorder comprising a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a pharmaceutical composition for inducing anti-stress, anti-anxiety and/or anti-depressant activities comprising a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient.

SULFAMATE DERIVATIVE COMPOUND FOR USE IN PREVENTING OR TREATING EPILEPSY

The present invention relates to a pharmaceutical composition for treating or preventing epilepsy containing a sulfamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention epilepsy comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of epilepsy.

Highly diastereoselective total syntheses of (+)-7-epigoniodiol, (-)-8-epigoniodiol, and (+)-9-deoxygoniopypyrone

An expedient concise total synthesis of (+)-7-epigoniodiol, (-)-8-epigoniodiol, and (+)-9-deoxygoniopypyrone is accomplished. The key transformations include a catalytic hydroxylation and base-mediated N-(acetyl)oxazolidinone addition reactions, which cou

PHENYLALKYL SULFAMATE COMPOUND AND MUSCLE RELAXANT COMPOSITION COMPRISING THE SAME

The present invention relates to novel phenylalkyl sulfamate compounds, a method for preventing or treating a disease associated with muscle spasm. The present invention ensures the enhancement of muscle relaxation activity essential for alleviation of muscle spasm, such that it is promising for preventing or treating various diseases associated with muscle spasm.

Total synthesis and cytotoxicity of (+)- and (-)-goniodiol and 6-epi-goniodiol. Construction of α,β-unsaturated lactones by ring-closing metathesis

(+)-Goniodiol, a potent and selective cytotoxin, and (-)-6-epi-goniodiol, as well as their enantiomers, have been synthesized starting from cinnamyl alcohol. The key steps of the synthesis were Sharpless asymmetric epoxidation and cyclization of an acrylate derivative using ring-closing metathesis reaction. The cytotoxicity of both enantiomers of goniodiol and 6-epi-goniodiol against HL-60 cells was examined.

S,O-acetals as novel "chiral aldehyde" equivalents

Palladium-catalyzed asymmetric allylic alkylations (AAA) to form "chiral aldehyde" equivalents were investigated. α-Acetoxysulfones were formed in high enantiomeric excess as single regioisomers in AAA reactions of allylic geminal dicarboxylates with sodi

Stereocontrolled synthesis of gem-difluoromethylenated goniodiols and goniothalamin epoxides based on ring-closing metathesis

An efficient and general method to stereoselectively synthesize gem-difluoromethylenated goniodiols and goniothalamin epoxides has been developed. The introduction of a gem-difluoromethyl-containing group was achieved by the reaction of aldehydes with 3-bromo-3,3-difluoropropene in the presence of indium. The gem-difluoromethylenated α,β-unsaturated- δ-lactone moiety was constructed through the ring-closing metathesis of highly electron-deficient gew-difluoromethylenated acryloyl esters by Grubbs' II catalyst in toluene at reflux. Georg Thieme Verlag Stuttgart.

On the selectivity of oxynitrilases towards α-oxygenated aldehydes

Different α-alkoxy and α,β-di-alkoxy substituted aldehydes have been submitted to the catalytic action of the oxynitrilases from almond (PaHNL) or from Hevea brasiliensis (HbHNL), in order to explore the possibility of using these enzymes for the preparation of complex cyanohydrins. The selectivity of both enzymes towards these compounds was found to be largely dependent on the substitutents, being low with the aldehydes carrying the sterically more demanding phenyl substituent. Contrary to the chemical addition of HCN, which always occurs with a slight preference for the formation of the anti diastereoisomers, the enzymatic cyanuration - occurring with a facial preference, Si or Re according to the biocatalyst used - gave a mixture of cyanohydrins that, depending on the starting enantiomeric aldehyde, can be enriched in the syn diastereoisomers.

Asymmetric syntheses of chiral allylic alcohols

Chiral allylic alcohols 2 can easily be obtained by elimination from iodo ketals 10. These are available from natural sources, or by application of the asymmetric Sharpless dihydroxylation to vinylogous esters 6, subsequent reduction, halogenation and elimination. This protocol allows the synthesis of highly functionalized allylic alcohols, which can be used in asymmetric Claisen rearrangements.