910550-48-0

Upstream product

• 910551-04-1 t-butyl [(2R)-4-[4-(4-methoxycarbonylbenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate 
• 691394-20-4 C₁₂H₁₄N₂O₃ 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 

Relevant academic research and scientific papers

Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: Synthesis, SAR and biological evaluation

Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. Several series of β-amino amide containing piperazine derivatives have been prepared and evaluated as a inhibitor of DPP4. Finally compound 5m was selected for further evaluation.

PIPERAZINYL COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable salt thereof: [wherein Ar is aryl or heteroaryl, optionally substituted; R1 is acyl; R2 is H or lower alkyl; R3 is H, and the like; R4 is H, and the like.] having the activity inhibiting DPP-IV ac