91056-79-0Relevant academic research and scientific papers
Modular Access to Substituted Azocanes via a Rhodium-Catalyzed Cycloaddition-Fragmentation Strategy
Shaw, Megan H.,Croft, Rosemary A.,Whittingham, William G.,Bower, John F.
, p. 8054 - 8057 (2015/07/15)
A short entry to substituted azocanes by a Rh-catalyzed cycloaddition-fragmentation process is described. Specifically, exposure of diverse N-cyclopropylacrylamides to phosphine-ligated cationic Rh(I) catalyst systems under a CO atmosphere enables the directed generation of rhodacyclopentanone intermediates. Subsequent insertion of the alkene component is followed by fragmentation to give the heterocyclic target. Stereochemical studies show, for the first time, that alkene insertion into rhodacyclopentanones can be reversible.
Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)
Mackinnon, Colin H.,Lau, Kevin,Burch, Jason D.,Chen, Yuan,Dines, Jonathon,Ding, Xiao,Eigenbrot, Charles,Heifetz, Alexander,Jaochico, Allan,Johnson, Adam,Kraemer, Joachim,Kruger, Susanne,Krülle, Thomas M.,Liimatta, Marya,Ly, Justin,Maghames, Rosemary,Montalbetti, Christian A.G.N.,Ortwine, Daniel F.,Pérez-Fuertes, Yolanda,Shia, Steven,Stein, Daniel B.,Trani, Giancarlo,Vaidya, Darshan G.,Wang, Xiaolu,Bromidge, Steven M.,Wu, Lawren C.,Pei, Zhonghua
, p. 6331 - 6335 (2013/11/19)
Inhibition of the non-receptor tyrosine kinase ITK, a component of the T-cell receptor signalling cascade, may represent a novel treatment for allergic asthma. Here we report the structure-based optimization of a series of benzothiazole amides that demons
1,4-disubstituted benzo-fused cycloalkyl urea compounds
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, (2015/04/15)
Disclosed are compounds of the formula (I) shown below which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds. wherein n, X, A, L, J, p, Q, Y and z are described herein.
