91057-86-2

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 108-94-1 cyclohexanone 
• 49653-17-0 ethyl 2-ethoxyglycolate 

Downstream Products

• 106975-25-1 ethyl (R)-2-hydroxy-2-cyclohexylacetate 
• 53585-93-6 (R)-(-)-hexahydromandelic acid 
• 24181-84-8 2-(2-Oxocyclohexanylidene) acetate d'ethyle E 
• 40785-55-5 (2-hydroxyphenyl)-glyoxylic acid ethyl ester 
• 1403380-87-9 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)cyclohex-1-en-1-yl]acetic acid 
• 1403381-38-3 ethyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)cyclohex-1-en-1-yl]acetate 
• 1403381-37-2 ethyl 2-(tert-butoxy)-2-{2-[(trifluoromethane)sulfonyloxy]cyclohex-1-en-1-yl}acetate 
• 1403381-36-1 ethyl 2-(tert-butoxy)-2-(2-oxocyclohexyl)acetate 
• 24731-17-7 ethyl 2-(2-oxocyclohexyl)acetate 
• 91690-93-6 (RS)-dimethylamino-((RS)-2-oxo-cyclohexyl)-acetic acid ethyl ester 
• 67715-07-5 2-(6-oxocyclohex-1-en-1-yl)acetic acid 
• 24124-06-9 2-(6-Oxocyclohex-1-enyl) acetate d'ethyle 
• 869369-37-9 (6-hydroxy-cyclohex-1-enyl)-acetic acid ethyl ester 
• 24181-84-8 2-(2-Oxocyclohexanylidene) acetate d'ethyle Z 

Relevant academic research and scientific papers

Fe(III)-Catalyzed Diastereoselective Friedel-Crafts Alkylation-Hemiketalization-Lactonization Cascade for the Synthesis of Polycyclic Bridged 2-Chromanol Lactones

An unprecedented Fe(III)-catalyzed Friedel-Crafts alkylation-hemiketalization-lactonization cascade of electron-rich hydroxy arenes and distinctively functionalized unsaturated 4-keto esters is developed for the construction of polycyclic bridged 2-chroma

A 2 - (2-hydroxy-phenyl) - 2-phenoxyacetic acid ester synthetic method

The invention discloses a synthetic method for 2-(2-hydroxyphenyl)-2-oxyacetate. The method comprises the following steps: taking cyclohexanone and glyoxylate as raw materials, producing an Aldol condensation reaction through catalysis at a room temperatu

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

Bronsted acid catalyzed asymmetric aldol reaction: A complementary approach to enamine catalysis

A syn-enantioselective aldol reaction has been developed using Bronsted acid catalysis based on H8-BINOL-derived phosphoric acids. This method affords an efficient synthesis of various β-hydroxy ketones, some of which could not be synthesized u

Inorganic ammonium salts as catalysts for direct aldol reactions in the presence of water

Inorganic ammonium salts catalyze the direct aldol reaction between unmodified ketones and aldehydes to furnish the corresponding β-hydroxy ketones in aqueous media. The reactions are highly chemoselective and operationally simple.

Organocatalytic enantioselective synthesis of secondary α-hydroxycarboxylates

Enantioenriched secondary α-hydroxycarboxylates have been synthesized in good yields and enantioselectivities by using the cross-aldol reaction of ketones and ethyl glyoxylate with a proline-derived dipeptide as the catalyst. Georg Thieme Verlag Stuttgart

Divergent enantioselective synthesis of (-)-galanthamine and (-)-morphine

An efficient divergent synthetic strategy for the synthesis of the opiate and amaryllidaceae alkaloids emerges by employing a Pd-catalyzed asymmetric allylic alkylation (AAA) to set the stereochemistry. Three generations of syntheses of galanthamine are discussed in detail with particular focus on the scope of the palladium-catalyzed AAA reactions and intramolecular Heck reactions. The pivotal tricyclic intermediate is available in six steps from 2-bromovanillin and the monoester of methyl 6-hydroxycyclohexene-1-carboxylate. This intermediate requires only two steps to convert to (-)-galanthamine. Using a Heck vinylation, we found that the fourth ring of codeine/morphine could be formed. The final ring formation involves a novel visible light-promoted hydroamination. Thus, six steps are required to convert the pivotal tricyclic intermediate into codeine, which has been demethylated in high yield to morphine.

Synthetic utility of bowl-shaped tris(2,6-diphenyl-benzyl)silyl glyoxylate as a stable glyoxylate: Application to highly diastereoselective aldol reactions

A stable glyoxylate can be successfully applied to both syn- and anti-selective aldol reactions by using two different kinds of ordinary Lewis acids. Thus, treatment of bowl-shaped tris(2,6-diphenylbenzyl)silyl glyoxylate 1 with enol silyl ether under the influence of BF3·OEt2 gave syn-aldol product, while the use of TiCl4 afforded anti-aldol product with >97% selectivity.