910581-15-6

Upstream product

• 100-39-0 benzyl bromide 
• 10385-30-5 4-(benzyloxy)butanoic acid 
• 4541-14-4 4-benzyloxy-butan-1-ol 
• 910581-09-8 3-(4-(benzyloxy)butanoyl)oxazolidin-2-one 
• 5292-43-3 bromoacetic acid tert-butyl ester 

Downstream Products

• 910581-22-5 5-benzyloxy-3-(2-oxooxazolidine-3-carbonyl)pentanoic acid 
• 910581-52-1 2-(2-(benzyloxy)ethyl)-N⁴-hydroxy-N¹-(prop-2-ynyl)succinamide 
• 910581-36-1 2-(2-(benzyloxy)ethyl)-4-oxo-4-(trityloxyamino)butanoic acid 
• 910581-44-1 2-(2-(benzyloxy)ethyl)-N¹-(prop-2-ynyl)-N⁴-(trityloxy)succinamide 
• 910581-29-2 5-benzyloxy-3-(2-oxooxazolidine-3-carbonyl)-N-(trityloxy)pentanamide 

Relevant academic research and scientific papers

Rapid assembly of matrix metalloprotease inhibitors using click chemistry

A panel of 96 metalloprotease inhibitors was assembled using "click chemistry" by reacting eight zinc-binding hydroxamate warheads with 12 azide building blocks. Screens of the bidentate compounds against representative metalloproteases provided discerning inhibition fingerprints, revealing compounds with low micromolar potency against MMP-7. The relative ease and convenience of the strategy in constructing focused chemical libraries for rapid in situ screening of MMPs is thereby demonstrated.

"Click" synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

By using "Click Chemistry", we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments. The Royal Society of Chemistry 2006.