91061-03-9Relevant academic research and scientific papers
Ligand-Controlled Palladium-Catalyzed Carbonylation of Alkynols: Highly Selective Synthesis of α-Methylene-β-Lactones
Beller, Matthias,Ge, Yao,Jackstell, Ralf,Jiao, Haijun,Liu, Jiawang,Spannenberg, Anke,Yang, Ji,Ye, Fei
, p. 21585 - 21590 (2020)
The first general and regioselective Pd-catalyzed cyclocarbonylation to give α-methylene-β-lactones is reported. Key to the success for this process is the use of a specific sterically demanding phosphine ligand based on N-arylated imidazole (L11) in the presence of Pd(MeCN)2Cl2 as pre-catalyst. A variety of easily available alkynols provide under additive-free conditions the corresponding α-methylene-β-lactones in moderate to good yields with excellent regio- and diastereoselectivity. The applicability of this novel methodology is showcased by the direct carbonylation of biologically active molecules including natural products.
A Switchable Domino Process for the Construction of Novel CO2-Sourced Sulfur-Containing Building Blocks and Polymers
Ouhib, Farid,Grignard, Bruno,Van Den Broeck, Elias,Luxen, André,Robeyns, Koen,Van Speybroeck, Veronique,Jerome, Christine,Detrembleur, Christophe
, p. 11768 - 11773 (2019)
α-Alkylidene cyclic carbonates (αCCs) recently emerged as attractive CO2-sourced synthons for the construction of complex organic molecules. Herein, we report the transformation of αCCs into novel families of sulfur-containing compounds by orga
When is a polymorph not a polymorph? Helical trimeric O-H···O synthons in trans-1,4-diethynylcyclohexane-1,4-diol
Bilton, Clair,Howard, Judith A. K.,Madhavi, N. N. Laxmi,Nangia, Ashwini,Desiraju, Gautam R.,Allen, Frank H.,Wilson, Chick C.
, p. 1675 - 1676 (1999)
Two polymorphs (A and B) of trans-1,4-diethynylcyclohexane-1,4-diol represent a unique example of the simultaneous occurrence of both conformational polymorphism and conformational isomorphism, while a pseudopolymorphic monohydrate is closely related.
Competition between hydrogen bonds and halogen bonds: A structural study
Gamekkanda, Janaka C.,Sinha, Abhijeet S.,Desper, John,Dakovi?, Marijana,Aaker?y, Christer B.
, p. 10539 - 10547 (2018/07/06)
The competition and balance between intermolecular hydrogen bonds (HBs) and halogen bonds (XBs) were explored by co-crystallizing tetra-functionalized (2 × HB (-OH) and 2 × XB (-CC-I)) molecules, trans-1,4-bis(iodoethynyl)cyclohexane-1,4-diol (D1) and cis
Synthesis of acetylenic alcohols with calcium carbide as the acetylene source
Sum, Yin Ngai,Yu, Dingyi,Zhang, Yugen
supporting information, p. 2718 - 2721 (2013/10/08)
Propargyl alcohols containing a terminal alkyne group are highly important and versatile intermediates. Here, we report the synthesis of these compounds from an inexpensive and renewable resource, calcium carbide (CaC2). No metal catalysts are required in this new protocol and the reactions take place under very mild conditions.
Synthesis and First Molecular Structure of a Bis-2-spiro-1-boraadamantane Derivative
Wagner, Carl E.,Shea, Kenneth J.
, p. 313 - 316 (2007/10/03)
(Matrix presented) A new method for synthesizing the 2-spiro- boraadamantane pyridine complex (2) from 1-ethynylcyclohexylmethyl ether has been developed. The chemistry has been applied to the synthesis of bis-2-spiro-1-boraadamantane-pyridine (1) from tr
