910655-40-2Relevant academic research and scientific papers
Assymetric formal synthesis of (-)-formoterol and (-)-tamsulosin
Kim, Yongeun,Kang, Lae-Sung,Ha, Hyun-Joon,Ko, Seung Whan,Lee, Won Koo
, p. 2243 - 2248 (2008/09/17)
Biologically important (2R)-2-amino-3-phenylpropanes consisted in commercial drugs including (R,R)-formoterol, and (R)-tamsulosin were prepared from chiral (2R)-aziridine-2-carboxylate without any chromatographic separation. Key reactions include regio- and stereoselective ring opening reaction of aziridin-2-yl-phenylmethanol and subsequent cyclization toward enantiopure 4,5-disubastitued oxazolidin-2-ones as synthetic intermediates.
