936628-48-7

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 68820-82-6 (2R)-1[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 397849-98-8 [1'(R)-α-methylbenzyl]aziridine-2(R)-carboxylate (-)-menthol ester 

Downstream Products

• 910655-39-9 1-{(2R)-1-[(1R)-1-phenylethyl]-aziridin-2-yl}-3-buten-1-one 
• 910655-40-2 (2R,1'R)-2-(1'-phenylethyl)aziridinyl 4-methoxyphenyl ketone 
• 1278522-23-8 1-{(R)-1-[(R)-1-phenylethyl]aziridin-2-yl}but-2-yn-1-one 
• 1278522-26-1 (2R,3R,E)-3-(t-butyldimethylsilyloxy)-2-[(R)-1-phenylethylamino]hex-4-enyl acetate 
• 1278522-25-0 (R)-2-[(S,E)-1-(t-butyldimethylsilyloxy)but-2-enyl]-1-[(R)-1-phenylethyl]aziridine 
• 1278522-24-9 (R)-2-[(R,E)-1-(t-butyldimethylsilyloxy)but-2-enyl]-1-[(R)-1-phenylethyl]aziridine 
• 1204694-62-1 (S)-1-{(R)-1-[(R)-1-phenylethyl]aziridin-2-yl}but-2-yn-1-ol 
• 1204694-63-2 (R)-1-{(R)-1-[(R)-1-phenylethyl]aziridin-2-yl}but-2-yn-1-ol 
• 1278522-31-8 (R)-4-[(S,E)-1-(t-butyldimethylsilyloxy)but-2-enyl]-3-[(R)-1-phenylethyl]oxazolidin-2-one 
• 1278522-30-7 (R)-4-[(R,E)-1-(t-butyldimethylsilyloxy)but-2-enyl]-3-[(R)-1-phenylethyl]oxazolidin-2-one 
• 1278522-29-4 (2R,3S,E)-3-(t-butyldimethylsilyloxy)-2-[(R)-1-phenylethylamino]hex-4-en-1-ol 
• 1278522-28-3 (2R,3R,E)-3-(t-butyldimethylsilyloxy)-2-[(R)-1-phenylethylamino]hex-4-en-1-ol 
• 1278522-27-2 (2R,3S,E)-3-(t-butyldimethylsilyloxy)-2-[(R)-1-phenylethylamino]hex-4-enyl acetate 
• 936628-39-6 (1S,2E)-1-{(2R)-1-[(1R)-1-phenylethyl]-aziridin-2-yl}-2-buten-1-ol 

Relevant academic research and scientific papers

Asymmetric synthesis of 1-deoxyazasugars from chiral aziridines

A general and facile synthesis of enantiopure 1-deoxyazasugars was achieved from stereoselective dihydroxylation of a common synthetic intermediate, piperidine ring fused oxazolidin-2-one, originating from a commercially available starting substrate, chiral aziridine-2-carboxylate, in high yields. The Royal Society of Chemistry 2011.

Syntheses of tetrahydropyridin-3-ol and tetrahydroazepin-3-ol from a chiral aziridine-2-carboxylate

A method for the stereoselective preparation of 1,2,3,6-tetrahydropyridin-3-ols and 2,3,4,7-tetrahydro-1H-azepin-3-ols, potentially versatile intermediates in the asymmetric synthesis of various piperidine alkaloids and azasugars, has been developed. The

Assymetric formal synthesis of (-)-formoterol and (-)-tamsulosin

Biologically important (2R)-2-amino-3-phenylpropanes consisted in commercial drugs including (R,R)-formoterol, and (R)-tamsulosin were prepared from chiral (2R)-aziridine-2-carboxylate without any chromatographic separation. Key reactions include regio- and stereoselective ring opening reaction of aziridin-2-yl-phenylmethanol and subsequent cyclization toward enantiopure 4,5-disubastitued oxazolidin-2-ones as synthetic intermediates.