91066-23-8 Usage
Uses
Used in Pharmaceutical Industry:
5-(3-CHLOROPROPYL)-3-PHENYL-1,2,4-OXADIAZOLE is used as a building block in the synthesis of various bioactive molecules for pharmaceutical applications. Its unique structure and properties make it a promising intermediate in the development of novel compounds with specific therapeutic effects.
Used in Agrochemical Industry:
5-(3-CHLOROPROPYL)-3-PHENYL-1,2,4-OXADIAZOLE is used as a key intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its potential biological activities and chemical properties contribute to the development of effective and targeted agrochemical products.
Used in Materials Science:
5-(3-CHLOROPROPYL)-3-PHENYL-1,2,4-OXADIAZOLE is used in the development of novel materials with specific properties, such as high thermal stability, flame retardancy, and electrical conductivity. Its versatile chemical structure allows for the creation of materials with tailored properties for various applications in materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 91066-23-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,0,6 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 91066-23:
(7*9)+(6*1)+(5*0)+(4*6)+(3*6)+(2*2)+(1*3)=118
118 % 10 = 8
So 91066-23-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H11ClN2O/c12-8-4-7-10-13-11(14-15-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2
91066-23-8Relevant academic research and scientific papers
Synthesis and Biological Evaluation of Sigma-1 (σ1) Receptor Ligands Based on Phenyl-1,2,4-oxadiazole Derivatives
Cao, Xudong,Yao, Zhongyuan,Dou, Fei,Zhang, Yifang,Qiu, Yinli,Zhao, Song,Xu, Xiangqing,Liu, Xin,Liu, Bi-Feng,Chen, Yin,Zhang, Guisen
, (2019/02/26)
In this study, a series of phenyl-1,2,4-oxadiazole derivatives were synthesized and evaluated for anti-allodynic activity. Structure–activity relationship studies identified 1-{4-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]butyl}piperidine (39) with excellent affinity for the σ1 receptor and selectivity for the σ2 receptor, with poor activity to other central nervous system neurotransmitter receptors and transporters associated with pain. Compound 39 exhibited dose-dependent efficacy in suppressing the formalin-induced flinching and attenuating mechanical allodynia in chronic constriction injury-induced neuropathic rats. These results suggest that compound 39 exerts potent antihyperalgesic activity and could be considered as a promising candidate for treating neuropathic pain.
