91076-99-2

Usage

Uses

Used in Pharmaceutical Synthesis:
3-AMINO-5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER is utilized as a key intermediate in the synthesis of pharmaceutical drugs for its ability to contribute to the development of new therapeutic agents.
Used in Agrochemical Development:
In the agrochemical industry, 3-AMINO-5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER is employed as a building block in the creation of new agrochemicals, potentially enhancing crop protection and yield.
Used in Organic Chemistry Research:
3-AMINO-5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER serves as a valuable compound in organic chemistry research, where it is used to explore novel chemical reactions and mechanisms, contributing to the advancement of the field.
Used in Material Science:
3-AMINO-5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER is applied in material science for the development of new materials with specific properties, such as those with enhanced stability or reactivity.
Used in Polymer and Resin Production:
In the industrial sector, 3-AMINO-5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER is used in the production of certain types of polymers and resins, where its unique chemical structure imparts desirable characteristics to the final products.

InChI:InChI=1/C12H10N2O4S/c1-18-12(15)11-9(13)6-10(19-11)7-2-4-8(5-3-7)14(16)17/h2-6H,13H2,1H3

Upstream product

• 78583-88-7 (E)-3-Chloro-3-(4-nitro-phenyl)-acrylonitrile 
• 2365-48-2 Methyl thioglycolate 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 832102-17-7 3-(dimethylamino-methyleneamino)-5-(4-nitro-phenyl)-thiophene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

The clinical evidence for the success of tyrosine kinase inhibitors in combination with microtubule-targeting agents prompted us to design and develop single agents that possess both epidermal growth factor receptor (EGFR) kinase and tubulin polymerization inhibitory properties. A series of 6-aryl/heteroaryl-4-(3′,4′,5′-trimethoxyanilino)thieno[3,2-d]pyrimidine derivatives were discovered as novel dual tubulin polymerization and EGFR kinase inhibitors. The 4-(3′,4′,5′-trimethoxyanilino)-6-(p-tolyl)thieno[3,2-d]pyrimidine derivative 6g was the most potent compound of the series as an antiproliferative agent, with half-maximal inhibitory concentration (IC50) values in the single- or double-digit nanomolar range. Compound 6g bound to tubulin in the colchicine site and inhibited tubulin assembly with an IC50 value of 0.71 μM, and 6g inhibited EGFR activity with an IC50 value of 30 nM. Our data suggested that the excellent in vitro and in vivo profile of 6g may be derived from its dual inhibition of tubulin polymerization and EGFR kinase.

Novel small molecule inhibitors targeting the "switch region" of bacterial RNAP: Structure-based optimization of a virtual screening hit

Rising resistance against current antibiotics necessitates the development of antibacterial agents with alternative targets. The "switch region" of RNA polymerase (RNAP), addressed by the myxopyronins, could be such a novel target site. Based on a hit can

The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in